Santos Heitor O, Teixeira Filipe J
School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Brazil.
Laboratory of Physiology and Biochemistry of Exercise Faculty of Human Kinetics, Universidade de Lisboa, Cruz Quebrada, Portugal.
Aging Male. 2020 Dec;23(5):669-678. doi: 10.1080/13685538.2019.1573220. Epub 2019 Feb 15.
Hypogonadism affects an extensive part of the male population, especially among the elderly. The quest for treatment regarding low levels of serum testosterone and male infertility has, therefore, worldwide relevance. Zinc has important biological actions insofar as the male reproductive physiology and endocrine system. In general, a common and safe recommendation for zinc in the treatment of male hypogonadism is 220 mg of zinc sulfate (equivalent to 50 mg of elemental zinc) twice a day, over one to four months. Additionally, it may be further required to extend, both the treatment, dose and daily fractionation of this mineral. Albeit medicinal doses of zinc may increase total testosterone and improve sperm count, the current body of evidence does not suggest broad recommendations regarding the use of zinc for all types of hypogonadism. In many cases, the use of zinc supplements is insufficient, with the use of surgery and drugs being required for an effective treatment.
性腺功能减退影响着广大男性群体，尤其是老年人。因此，寻求治疗血清睾酮水平低下和男性不育症的方法具有全球意义。锌在男性生殖生理和内分泌系统方面具有重要的生物学作用。一般来说，治疗男性性腺功能减退时，锌的常见且安全的推荐用量是硫酸锌220毫克（相当于元素锌50毫克），每天两次，持续一至四个月。此外，可能还需要进一步延长这种矿物质的治疗时间、剂量和每日分次服用量。尽管药用剂量的锌可能会增加总睾酮水平并改善精子数量，但目前的证据并不支持对所有类型的性腺功能减退都广泛推荐使用锌。在许多情况下，使用锌补充剂并不足够，还需要进行手术和使用药物才能有效治疗。
