Vilar Neto José de Oliveira, de Moraes Wilson Max Almeida Monteiro, Pinto Daniel Vieira, da Silva Carlos Alberto, Caminha Juan de Sá Roriz, Nunes Filho Júlio César Chaves, Reis Caio Eduardo Gonçalves, Prestes Jonato, Santos Heitor O, De Francesco Daher Elizabeth
Graduate Program in Medical Sciences, Federal University of Ceará, Fortaleza 60355-636, Brazil.
Physical Education and Sports Institute, Federal University of Ceará, Fortaleza 60355-636, Brazil.
Nutrients. 2025 Apr 6;17(7):1275. doi: 10.3390/nu17071275.
: L. Zygophyllaceae (TT) is a plant that has been claimed to increase testosterone levels and improve sexual function, particularly erectile dysfunction, with potential benefits for male sexual health. : This systematic review aimed to evaluate the effectiveness of TT supplementation in improving sexual function and serum testosterone levels in men. : We conducted a systematic review adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After searching the literature ( = 162), 52 studies were selected for full-text reading, and 10 studies were eligible for this review, comprising 9 clinical trials and 1 quasi-experimental study (a study without a control). The Jadad score revealed low methodological quality for 50% of the studies. : The studies involved 15 to 172 participants (total = 483) aged between 16 and 70 years with different health conditions: healthy men ( = 5), oligozoospermia ( = 1), erectile dysfunction ( = 1), erectile dysfunction associated with hypogonadism ( = 2), and unexplained infertility ( = 1). TT supplementation at doses of 400 to 750 mg/d for 1 to 3 months improved erectile dysfunction in 3 of the 5 studies that assessed this parameter. Eight out of ten studies did not report significant changes in androgen profile following TT supplementation, but the subjects in the neutral studies did not have low androgen levels at baseline. Therefore, only 2 studies showed significant intra-group increase in total testosterone levels, which had low clinical magnitude (60-70 ng/dL) and involved subjects with hypogonadism. : TT supplementation has a low level of evidence regarding its effectiveness in improving erectile function in men with erectile dysfunction, and no robust evidence was found for increasing testosterone levels.
刺山柑科植物（TT）是一种据称能提高睾酮水平并改善性功能，尤其是勃起功能障碍，对男性性健康有潜在益处的植物。本系统评价旨在评估补充TT对改善男性性功能和血清睾酮水平的有效性。我们按照系统评价和Meta分析的首选报告项目（PRISMA）指南进行了一项系统评价。在检索文献（n = 162）后，选择了52项研究进行全文阅读，其中10项研究符合本评价标准，包括9项临床试验和1项准实验研究（无对照研究）。Jadad评分显示50%的研究方法学质量较低。这些研究涉及15至172名年龄在16至70岁之间、健康状况各异的参与者（总计 = 483人）：健康男性（n = 5）、少精子症患者（n = 1）、勃起功能障碍患者（n = 1）、性腺功能减退伴勃起功能障碍患者（n = 2）以及不明原因不孕症患者（n = 1）。在评估该参数的5项研究中，有3项研究显示，每天补充400至750毫克TT，持续1至3个月，可改善勃起功能障碍。十项研究中有八项未报告补充TT后雄激素水平有显著变化，但中性研究中的受试者基线时雄激素水平并不低。因此，只有两项研究显示组内总睾酮水平有显著升高，其临床幅度较低（60 - 70 ng/dL），且涉及性腺功能减退的受试者。关于补充TT对改善勃起功能障碍男性勃起功能的有效性，证据水平较低，未发现增加睾酮水平的有力证据。
