Huang Qianqian, Wu Haiying, Xiao Xiangxin, Qin Xiaoming, Liu Suqing
College of Food Science and Technology Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Science and Technology Innovation Center for Subtropical Fruit and Vegetable Processing Zhanjiang China.
National Research and Development Branch Center for Shellfish Processing Zhanjiang China.
Food Sci Nutr. 2024 May 13;12(8):5572-5586. doi: 10.1002/fsn3.4213. eCollection 2024 Aug.
Oyster peptide (OP) and extract (PGE) were used as raw materials. The optimal formulation of the pressed candy (PC) was optimized by one-way experiment and D-optimal mixture experiment design, and animal experiment was used to evaluate the effect of PC on male sexual dysfunction. The results showed that PC intervention significantly improved the sexual behavior of male mice with sexual dysfunction, including a significant shortening of the mount latency (ML) and intromission latency, and a significant increase in the mount frequency (MF) and intromission frequency (IF). At the same time, the concentrations of serum testosterone (T) and luteinizing hormone (LH) in mice were restored, and the erectile parameters and pathological changes of penile tissue were improved. Further studies found that PC intervention increased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and reduced the content of malondialdehyde (MDA) in testicular tissue. In addition, PC intervention improved testicular tissue morphology. In conclusion, the obtained PC has good taste quality, and the relevant quality indicators are qualified. It has a good ameliorative effect on male sexual dysfunction and may be a potential dietary supplement.
以牡蛎肽（OP）和提取物（PGE）为原料。通过单因素试验和D-最优混合试验设计优化压片糖果（PC）的最佳配方，并通过动物实验评估PC对男性性功能障碍的影响。结果表明，PC干预显著改善了性功能障碍雄性小鼠的性行为，包括显著缩短爬跨潜伏期（ML）和插入潜伏期，显著增加爬跨频率（MF）和插入频率（IF）。同时，小鼠血清睾酮（T）和黄体生成素（LH）的浓度得到恢复，阴茎组织的勃起参数和病理变化得到改善。进一步研究发现，PC干预增加了睾丸组织中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）的活性，并降低了丙二醛（MDA）的含量。此外，PC干预改善了睾丸组织形态。总之，所得PC口感品质良好，相关质量指标合格。它对男性性功能障碍有良好的改善作用，可能是一种潜在的膳食补充剂。
