Centre of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, India.
Prince Sultan Military College of Health Sciences, Dhahran 34313, Saudi Arabia.
Curr Pharm Des. 2018;24(42):5062-5071. doi: 10.2174/1381612825666190215122208.
Personalized medicines are becoming more popular as they enable the use of patient's genomics and hence help in better drug design with fewer side effects. In fact, several doses can be combined into one dosage form which suits the patient's demography. 3 Dimensional (3D) printing technology for personalized medicine is a modern day treatment method based on genomics of patient.
3D printing technology uses digitally controlled devices for formulating API and excipients in a layer by layer pattern for developing a suitable personalized drug delivery system as per the need of patient. It includes various techniques like inkjet printing, fused deposition modelling which can further be classified into continuous inkjet system and drop on demand. In order to formulate such dosage forms, scientists have used various polymers to enhance their acceptance as well as therapeutic efficacy. Polymers like polyvinyl alcohol, poly (lactic acid) (PLA), poly (caprolactone) (PCL) etc can be used during manufacturing.
Varying number of dosage forms can be produced using 3D printing technology including immediate release tablets, pulsatile release tablets, and transdermal dosage forms etc. The 3D printing technology can be explored successfully to develop personalized medicines which could play a vital role in the treatment of lifethreatening diseases. Particularly, for patients taking multiple medicines, 3D printing method could be explored to design a single dosage in which various drugs can be incorporated. Further 3D printing based personalized drug delivery system could also be investigated in chemotherapy of cancer patients with the added advantage of the reduction in adverse effects.
In this article, we have reviewed 3D printing technology and its uses in personalized medicine. Further, we also discussed the different techniques and materials used in drug delivery based on 3D printing along with various applications of the technology.
随着个性化药物的兴起，它们能够利用患者的基因组学信息，从而帮助更好地设计药物，减少副作用。事实上，几种剂量可以组合成一种适合患者特征的剂型。基于患者基因组学的 3D 打印技术是一种现代的个性化医学治疗方法。
3D 打印技术使用数字控制设备，按照患者的需求，以逐层的方式将 API 和赋形剂配方在一起，以开发合适的个性化药物输送系统。它包括各种技术，如喷墨打印、熔融沉积建模，后者又可以进一步分为连续喷墨系统和按需滴注。为了制定这种剂型，科学家们使用了各种聚合物来提高它们的接受度和治疗效果。在制造过程中，可以使用各种聚合物，如聚乙烯醇、聚乳酸（PLA）、聚己内酯（PCL）等。
使用 3D 打印技术可以生产出各种剂型，包括速释片剂、脉冲释放片剂、透皮剂型等。3D 打印技术可以成功地用于开发个性化药物，这在治疗危及生命的疾病方面可能发挥至关重要的作用。特别是对于需要服用多种药物的患者，可以探索 3D 打印方法来设计一种包含各种药物的单一剂型。此外，还可以研究基于 3D 打印的个性化药物输送系统，以减少不良反应的优势，用于癌症患者的化疗。
本文综述了 3D 打印技术及其在个性化医学中的应用。此外，还讨论了基于 3D 打印的药物输送中使用的不同技术和材料，以及该技术的各种应用。
