哥伦比亚安蒂奥基亚省百草枯中毒负担
Burden of paraquat poisoning in the department of Antioquia, Colombia.
作者信息
Buendía Jefferson Antonio, Chavarriaga Gabriel Jaime Restrepo, Zuluaga Andrés F
机构信息
Grupo de Investigación en farmacología y toxicología, Centro de Información y Estudio de Medicamentos y Tóxicos (CIEMTO), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
出版信息
BMC Pharmacol Toxicol. 2019 Feb 15;20(1):11. doi: 10.1186/s40360-019-0291-0.
BACKGROUND
Paraquat (PQ) poisoning is a public health problem in many regions of Colombia. This study aimed to estimate the burden of PQ poisoning in the Department of Antioquia, Colombia.
METHODS
Disability-adjusted life year (DALYs) were calculated as the sum of years of life lost (YLL) and years of life lived with disability (YLD) due to paraquat poisoning in Antioquia; a bootstrapped method with 1000 iterations was used to estimate each statistical parameter using the package DALY calculator in R. For this instance, the annual incidence of paraquat poisoning was obtained from the reported surveillance data according to regional Government.
RESULTS
From 2010 to 2016, 3299 DALYs were estimated in the department of Antioquia for PQ intoxication, with a rate of 53.4 DALYs per 100,000 inhabitants. The majority of the DALYs (2852 DALYs) were generated for men ranging from 15 to 44 years old.
CONCLUSION
The rate of DALYs reported here is higher than that reported by all chemical poisonings. Better strategies to regulate and restrict the market of this dangerous products are required in Colombia.
背景
百草枯中毒是哥伦比亚许多地区的一个公共卫生问题。本研究旨在估算哥伦比亚安蒂奥基亚省百草枯中毒的负担。
方法
伤残调整生命年（DALYs）通过安蒂奥基亚省因百草枯中毒导致的生命损失年数（YLL）和伤残生命年数（YLD）之和来计算；使用R语言中的DALY计算器软件包，采用1000次迭代的自助法来估算每个统计参数。在此案例中，百草枯中毒的年发病率是根据地区政府报告的监测数据得出的。
结果
2010年至2016年期间，安蒂奥基亚省因百草枯中毒估算出3299个伤残调整生命年，每10万居民中有53.4个伤残调整生命年。大部分伤残调整生命年（2852个）是由15至44岁的男性产生的。
结论
此处报告的伤残调整生命年率高于所有化学中毒报告的比率。哥伦比亚需要采取更好措施来监管和限制此类危险产品的市场。
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