临床神经毒性研究更新会议总结
Summary of the Update Session on Clinical Neurotoxicity Studies.
作者信息
Pinyavat Teeda, Warner David O, Flick Randall P, McCann Mary Ellen, Andropoulos Dean B, Hu Danquig, Sall Jeffrey W, Spann Marisa N, Ing Caleb
机构信息
Departments of *Anesthesiology#Psychiatry, Columbia University College of Physicians and Surgeons, New York, NYDepartments of †Anesthesiology‡Pediatrics, Mayo Clinic College of Medicine, Rochester, MN§Department of Anesthesiology, Harvard Medical School, Boston, MA∥Department of Anesthesiology and Department of Pediatrics, Baylor College of Medicine, Houston, TX¶Department of Anesthesiology and Perioperative Care, University of California San Francisco School of Medicine, San Francisco, CA.
出版信息
J Neurosurg Anesthesiol. 2016 Oct;28(4):356-360. doi: 10.1097/ANA.0000000000000347.
During the Fifth Pediatric Anesthesia Neurodevelopmental Assessment Symposium, experts and stakeholders met to present and discuss recent advances made in the study of neurodevelopmental outcomes after exposure to anesthetic drugs in infants and children. This article summarizes the update of 5 ongoing clinical studies: General Anesthesia compared to Spinal Anesthesia, Toxicity of Remifentanil and Dexmedetomidine, Mayo Anesthesia Safety in Kids, the University of California San Francisco human cohort study, and Columbia University Medical Center Neonatal Magnetic Resonance Imaging study. The purpose of this summary is to discuss the contributions and limitations of these studies, how they fit into the published literature, and what questions remain to be answered.
在第五届儿科麻醉神经发育评估研讨会上，专家和利益相关者齐聚一堂，介绍并讨论了婴幼儿接触麻醉药物后神经发育结局研究的最新进展。本文总结了5项正在进行的临床研究的最新情况：全身麻醉与脊髓麻醉的比较、瑞芬太尼和右美托咪定的毒性、梅奥儿童麻醉安全性研究、加利福尼亚大学旧金山分校人类队列研究以及哥伦比亚大学医学中心新生儿磁共振成像研究。本总结的目的是讨论这些研究的贡献与局限性、它们如何融入已发表的文献以及仍有待解答的问题。
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