Department of Anesthesiology, Columbia University Medical Center, New York, NY.
Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA.
J Neurosurg Anesthesiol. 2019 Jan;31(1):119-121. doi: 10.1097/ANA.0000000000000549.
Neuroimaging has been increasingly used as a modality to study the impact of pain, analgesia, and anesthetics on pediatric neurodevelopment. The sixth biennial Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) Symposium addressed the 2016 US Food and Drug Administration drug safety warning regarding the potential neurotoxic effects of commonly used anesthetic and sedative medications in children, and included a session discussing the use of various neuroimaging techniques, to detect structural, metabolic, and functional brain changes that can occur with exposure to pain and to anesthetic medications. The presenters concluded that advanced multimodal magnetic resonance imaging techniques are useful in detecting the aforementioned changes, which were found to be pain-specific and anesthetic agent-specific.
神经影像学已越来越多地被用作一种方式来研究疼痛、镇痛和麻醉对儿童神经发育的影响。第六届儿科麻醉神经发育评估（PANDA）研讨会讨论了 2016 年美国食品和药物管理局关于常用麻醉和镇静药物对儿童潜在神经毒性作用的药物安全警告，并包括一个讨论各种神经影像学技术的使用的环节，以检测与疼痛和麻醉药物暴露相关的结构、代谢和功能脑变化。演讲者得出的结论是，先进的多模态磁共振成像技术可用于检测上述变化，这些变化被发现是具有疼痛特异性和麻醉药物特异性的。
