Hussain Rehan M, Dubovy Sander R, Kuriyan Ajay E, Zhou Xiao Yi, Flynn Harry W, Albini Thomas A
Ophthalmic Surg Lasers Imaging Retina. 2019 Feb 1;50(2):125-131. doi: 10.3928/23258160-20190129-11.
The histologic findings of a subretinal band and epiretinal membrane (ERM) excised from two patients who developed retinal detachments (RDs) after non-U.S. Food and Drug Administration-regulated intravitreal "stem cell" injections are reported. Both membranes were composed of fibrocellular tissue that stained positively with Smooth Muscle Actin and Masson's trichrome, consistent with collagenous and smooth muscle composition. CD34 immunostain (for hematopoietic cells) was negative for the subretinal band and minimally positive for the ERM. The authors speculate that the "stem cells" may cause RDs by differentiation into myofibroblasts that cause tractional membranes, though further studies are warranted. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:125-131.].
报告了从两名在美国食品药品监督管理局（FDA）监管范围之外接受玻璃体内“干细胞”注射后发生视网膜脱离（RD）的患者身上切除的视网膜下带和视网膜前膜（ERM）的组织学发现。两个膜均由纤维细胞组织组成，平滑肌肌动蛋白和马松三色染色呈阳性，符合胶原和平滑肌成分。CD34免疫染色（针对造血细胞）对视网膜下带呈阴性，对ERM呈弱阳性。作者推测，“干细胞”可能通过分化为引起牵引膜的肌成纤维细胞而导致RD，不过仍需进一步研究。[《眼科手术、激光与视网膜成像》。2019；50：125 - 131。]
