Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Department of Anatomy and Cell Biology, George Washington University, Washington, District of Columbia.
Anat Rec (Hoboken). 2020 Jun;303(6):1689-1702. doi: 10.1002/ar.24088. Epub 2019 Mar 18.
Regenerative repair in response to wounding involves cell proliferation and migration. This is followed by the reestablishment of cell structure and organization and a dynamic process of remodeling and restoration of the injured cells' extracellular matrix microenvironment and the integration of the newly synthesized matrix into the surrounding tissue. Fibrosis in the lungs, liver, and heart can lead to loss of life and in the eye to loss of vision. Learning to control fibrosis and restore normal tissue function after injury repair remains a goal of research in this area. Here we use knowledge gained using the lens and the cornea to provide insight into how fibrosis develops and clues to how it can be controlled. The lens and cornea are less complex than other tissues that develop life-threatening fibrosis, but they are well characterized and research using them as model systems to study fibrosis is leading toward an improved understanding of fibrosis. Here we summarize the current state of the literature and how it is leading to promising new treatments. Anat Rec, 2019. © 2019 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.
再生修复反应涉及细胞增殖和迁移。接着，细胞结构和组织重新建立，细胞外基质微环境的重塑和修复以及新合成基质与周围组织的整合是一个动态过程。肺、肝和心脏的纤维化可导致生命损失，而眼睛的纤维化则可导致视力丧失。学习控制纤维化并在损伤修复后恢复正常组织功能仍然是该领域研究的目标。在这里，我们利用晶状体和角膜的知识来深入了解纤维化的发展，并提供控制纤维化的线索。晶状体和角膜比其他容易发生致命性纤维化的组织简单，但它们的特征明确，并且使用它们作为模型系统来研究纤维化的研究正在使人们对纤维化有更好的理解。在这里，我们总结了目前的文献状况以及它如何为有前途的新治疗方法提供线索。解剖记录，2019 年。 © 2019 作者。解剖记录由 Wiley 期刊出版，代表美国解剖学家协会。
