Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
J Clin Pharmacol. 2019 Jul;59(7):915-922. doi: 10.1002/jcph.1389. Epub 2019 Feb 15.
Although the medical profession strives for safe prescribing, most medications are unique challenges even when prescribed by an experienced provider. In this article we discuss the pitfalls associated with drug interactions between commonly used antibiotics and anticoagulants, the complexities associated with the administration of novel reversible anticoagulants, the often-overlooked severe adverse drug reactions from commonly used classes of medications such as corticosteroids, the nuances of managing an acetaminophen overdose, and uncommon yet serious adverse events associated with the use of contraceptive hormone drugs.
尽管医疗行业致力于安全处方，但即使是经验丰富的医生开具处方，大多数药物也具有独特的挑战。本文讨论了常用抗生素和抗凝剂之间药物相互作用的陷阱、新型可逆抗凝剂给药的复杂性、经常被忽视的常用药物类别（如皮质类固醇）引起的严重药物不良反应、对乙酰氨基酚过量的处理细节以及与避孕激素药物使用相关的罕见但严重的不良事件。
