Biozentrum and the Swiss Nanoscience Institute, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Biozentrum and the Swiss Nanoscience Institute, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Exp Cell Res. 2019 Apr 15;377(1-2):86-93. doi: 10.1016/j.yexcr.2019.02.009. Epub 2019 Feb 13.
Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time. This is vital for cell migration and proliferation as well as tissue morphogenesis and remodeling. While the force-sensing and force-transducing mechanisms are generally known, it remains unclear how mechanoresponsive transcription factors (TFs) are selectively translocated into the nucleus upon force activation. Such TFs include Yes-Associated Protein (YAP), Myocardin Related Transcription Factors (MRTFs), Hypoxia Induced Factors (HIFs) and others. Here, we discuss how the nucleocytoplasmic transport machinery intersects with mechanoresponsive TFs to facilitate their selective transport through nuclear pore complexes.
细胞通过一个称为机械转导的过程整合机械和生化信号，以在空间和时间上生成基本的基因表达模式。这对于细胞迁移和增殖以及组织形态发生和重塑至关重要。虽然力感应和力转导机制通常是已知的，但力激活时如何选择性地将机械响应转录因子（TFs）易位到核内仍然不清楚。这样的 TF 包括 YAP（Yes-Associated Protein）、肌球蛋白相关转录因子（MRTFs）、缺氧诱导因子（HIFs）等。在这里，我们讨论了核质转运机制如何与机械响应 TF 相交，以促进它们通过核孔复合体的选择性运输。
