Shen Xu-Cheng, Dai Xiang-Nong, Xie Zhi-Min, Li Ping, Lu Sha, Li Jia-Hao, Zhang Yi, Ye Xing-Dong
Department of Dermatology, Dermatology Institute of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510182, China.
Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, 510095, China.
Dermatol Ther (Heidelb). 2020 Apr;10(2):321-327. doi: 10.1007/s13555-020-00358-y. Epub 2020 Feb 21.
Patients with chromoblastomycosis (CBM) usually have a history of local skin damage related to outdoor activities, mainly manifested as chronic refractory proliferative pathologic changes. We report a case of a 56-year-old man with CBM, identified as Fonsecaea pedrosoi infection by fungal culture and gene sequencing. This patient was successfully treated with a regimen of oral itraconazole (ITZ) and terbinafine lasting 7 months. Through in vitro drug sensitivity tests, minimum inhibitory concentrations of amphotericin, ITZ, and terbinafine were 1 μg/ml, 0.25 μg/ml, and 1 μg/ml, respectively. In this case, terbinafine was found to be more effective than ITZ.
着色芽生菌病（CBM）患者通常有与户外活动相关的局部皮肤损伤史，主要表现为慢性难治性增殖性病理改变。我们报告1例56岁男性CBM患者，经真菌培养和基因测序确诊为裴氏瓶霉感染。该患者接受口服伊曲康唑（ITZ）和特比萘芬联合治疗7个月，治疗成功。通过体外药敏试验，两性霉素、ITZ和特比萘芬的最低抑菌浓度分别为1μg/ml、0.25μg/ml和1μg/ml。在本病例中，发现特比萘芬比ITZ更有效。
