Bonnet Mathilde, Maisonial-Besset Aurélie, Zhu Yingying, Witkowski Tiffany, Roche Gwenaëlle, Boucheix Claude, Greco Céline, Degoul Françoise
Université Clermont Auvergne, INSERM1071, Microbes, Intestins, Inflammation et Susceptibilité de l'hôte, 63001 Clermont-Ferrand CEDEX 1, France.
Université Clermont Auvergne, INSERM U1240, Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France.
Cancers (Basel). 2019 Feb 3;11(2):179. doi: 10.3390/cancers11020179.
Tetraspanins are exposed at the surface of cellular membranes, which allows for the fixation of cognate antibodies. Developing specific antibodies in conjunction with genetic data would largely contribute to deciphering their biological behavior. In this short review, we summarize the main functions of Tspan8/Co-029 and its role in the biology of tumor cells. Based on data collected from recently reported studies, the possibilities of using antibodies to target Tspan8 in immunotherapy or radioimmunotherapy approaches are also discussed.
四跨膜蛋白暴露于细胞膜表面，这使得同源抗体能够与之结合。结合遗传数据开发特异性抗体将极大地有助于解读它们的生物学行为。在这篇简短的综述中，我们总结了Tspan8/Co - 029的主要功能及其在肿瘤细胞生物学中的作用。基于最近报道的研究收集的数据，还讨论了在免疫治疗或放射免疫治疗方法中使用抗体靶向Tspan8的可能性。
