Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Commun Signal. 2023 May 19;21(1):118. doi: 10.1186/s12964-023-01142-z.
Blood-brain barrier (BBB) interface with multicellular structure controls strictly the entry of varied circulating macromolecules from the blood-facing surface into the brain parenchyma. Under several pathological conditions within the central nervous system, the integrity of the BBB interface is disrupted due to the abnormal crosstalk between the cellular constituents and the recruitment of inflammatory cells. Exosomes (Exos) are nano-sized extracellular vesicles with diverse therapeutic outcomes. These particles transfer a plethora of signaling molecules with the potential to modulate target cell behavior in a paracrine manner. Here, in the current review article, the therapeutic properties of Exos and their potential in the alleviation of compromised BBB structure were discussed. Video Abstract.
血脑屏障（BBB）与多细胞结构的界面严格控制着各种循环大分子从面向血液的表面进入脑实质。在中枢神经系统的几种病理条件下，由于细胞成分的异常串扰和炎症细胞的募集，BBB 界面的完整性被破坏。外泌体（Exos）是具有多种治疗效果的纳米大小的细胞外囊泡。这些颗粒传递大量信号分子，具有以旁分泌方式调节靶细胞行为的潜力。在当前的综述文章中，讨论了 Exos 的治疗特性及其在缓解受损 BBB 结构方面的潜力。视频摘要。
