氟氯吡啶在 90 天亚慢性毒性试验中雄性 Wistar 大鼠的经口无可见不良反应水平为 3mg/kg/天。
The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day.
机构信息
Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China.
出版信息
Int J Environ Res Public Health. 2019 Feb 14;16(4):553. doi: 10.3390/ijerph16040553.
A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide.
此前的研究中，雄性 Wistar 大鼠经口分别给予氟氯吡啶（FLC）3mg/kg 和 10mg/kg 进行了为期 90 天的毒性和毒代动力学研究。在 10mg/kg 剂量下，仍观察到对雄性大鼠生殖系统的明显毒性，给药 24 小时后仍检测到痕量 FLC，睾丸重量、附睾重量和血清睾酮显著降低，附睾精子畸形显著增加。3mg/kg 组未发现异常，表明 FLC 在雄性大鼠中的无观察到不良效应水平（NOAEL）为 3mg/kg/天，远低于欧洲食品安全局（EFSA）报告的 20mg/kg/天的剂量。因此，应更加关注这种除草剂。
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