Sireeratawong Seewaboon, Jaijoy Kanjana, Khonsung Parirat, Lertprasertsuk Nirush, Ingkaninan Kornkanok
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani, 12120, Thailand.
BMC Complement Altern Med. 2016 Jul 27;16:249. doi: 10.1186/s12906-016-1236-4.
Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematological, biochemical, and histopathological parameters.
Acute oral toxicity of Bacopa monnieri extract was studied in female rats by giving a single orally administered dose at a level of 5,000 mg/kg. The rats were monitored for toxic signs for 14 days. In the chronic toxicity test, groups of both female and male rats were given daily oral doses of B. monnieri extract at dose levels of either 30, 60, 300 or 1,500 mg/kg for 270 days. The behavior and health of the animals was then monitored. At the end of the observation period, the body and organ weights of the rats in each group were measured. Blood was collected and necropsy was performed to evaluate their hematology, blood clinical chemistry, and microanatomy.
The acute toxicity test found no significant differences between the experimental and the control group rats. In the chronic toxicity test, animal behavior and health of the experimental groups were normal, just as in the control rats. All values of other parameters assessed remained within the normal range.
A single oral administration of B. monnieri extract at the dose of 5,000 mg/kg did not cause any serious undesirable effects. B. monnieri extract at doses of 30, 60, 300 and 1,500 mg/kg given for 270 days did not produce any toxicity in rats.
假马齿苋是一种药用植物，长期以来一直用于阿育吠陀医学中，以增强脑功能和改善记忆力。我们研究的目的是通过评估血液学、生化和组织病理学参数，来识别和评估假马齿苋提取物对大鼠可能产生的毒性作用。
通过给雌性大鼠单次口服5000毫克/千克剂量的假马齿苋提取物，研究其急性口服毒性。对大鼠进行14天的毒性体征监测。在慢性毒性试验中，给雌性和雄性大鼠组每日口服剂量为30、60、300或1500毫克/千克的假马齿苋提取物，持续270天。然后监测动物的行为和健康状况。在观察期结束时，测量每组大鼠的体重和器官重量。采集血液并进行尸检，以评估其血液学、血液临床化学和微观解剖结构。
急性毒性试验发现实验组和对照组大鼠之间没有显著差异。在慢性毒性试验中，实验组动物的行为和健康状况正常，与对照大鼠一样。评估的所有其他参数值均保持在正常范围内。
单次口服5000毫克/千克剂量的假马齿苋提取物不会引起任何严重的不良影响。给予大鼠270天剂量为30、60、300和1500毫克/千克的假马齿苋提取物不会产生任何毒性。
