Liu Sisi, Zhao Guodong, Li Jun, Zhao Hongxia, Wang Yafeng, Chen Jingwen, Zhao Haidong
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116023, China.
General Surgery Department, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116023, China; College of Dalian Medical University, No. 28 Aixian Road, Dalian 116020, China.
Environ Res. 2017 Nov;159:1-8. doi: 10.1016/j.envres.2017.07.042. Epub 2017 Jul 28.
Polybrominated diphenylethers (PBDE) have been demonstrated to be associated with significant alterations in hormone levels in humans. However, yet few epidemiological human evidence has associated thyroid function with hydroxylated polybrominated diphenylethers (OH-PBDEs), which may be more potent in disrupting thyroid hormone homeostasis. In the present study, the body burdens of 7 PBDEs and 11 OH-PBDEs as well as the serum thyroid status were examined in a cohort of 33 thyroid cancer patients. The levels of ∑PBDEs and ∑OH-PBDEs ranged from 1.07 to 39ng/g lipid, and 0.01-0.46ng/g lipid, respectively. BDE-47, 6-OH-BDE-47 and 3-OH-BDE-47 were the predominant congeners. The associations between these PBDE congeners and thyroid function were not significant after controlling for sociodemographic characteristics, as well as the associations between OH-PBDEs and free T3. There were an inverse association between lg3-OH-BDE-47 and lgFT4 (free T4) but a positive association between lg4'-OH-BDE-49 and TSH. Both lgΣOH-PBDEs (the sum of HO-tetra-BDEs) and lgΣOH-PBDEs were significantly and positively associated with lgTSH. Our results are consistent with most human studies, suggesting that OH-PBDEs can alter thyroid function by enhancing the elimination of serum FT4 with elevated TSH levels. To our knowledge, this is the first study to examine and report associations between OH-PBDEs and thyroid function in a cancer population.
多溴二苯醚（PBDE）已被证明与人类激素水平的显著变化有关。然而，目前很少有流行病学证据表明甲状腺功能与羟基化多溴二苯醚（OH-PBDEs）有关，而OH-PBDEs可能在破坏甲状腺激素稳态方面更具效力。在本研究中，对33名甲状腺癌患者队列中的7种PBDEs和11种OH-PBDEs的体内负荷以及血清甲状腺状态进行了检测。∑PBDEs和∑OH-PBDEs的水平分别为1.07至39ng/g脂质和0.01至0.46ng/g脂质。BDE-47、6-OH-BDE-47和3-OH-BDE-47是主要的同系物。在控制了社会人口统计学特征后，这些PBDE同系物与甲状腺功能之间的关联并不显著，OH-PBDEs与游离T3之间的关联也不显著。lg3-OH-BDE-47与lgFT4（游离T4）之间呈负相关，而lg4'-OH-BDE-49与TSH之间呈正相关。lgΣOH-PBDEs（羟基化四溴二苯醚的总和）和lgΣOH-PBDEs均与lgTSH呈显著正相关。我们的结果与大多数人体研究一致，表明OH-PBDEs可通过提高TSH水平促进血清FT4的消除来改变甲状腺功能。据我们所知，这是第一项在癌症人群中研究并报告OH-PBDEs与甲状腺功能之间关联的研究。
