Maeda Tomoki, Iwata Hajime, Sekiguchi Kazuhito, Takahashi Mizuho, Ihara Kenji
Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.
Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.
Brain Dev. 2019 Jun;41(6):490-500. doi: 10.1016/j.braindev.2019.01.007. Epub 2019 Feb 12.
To clarify the morphologic characteristics of the brain, which are the foundation of the emergence of general movements (GMs) in very-low-birth-weight infants.
Prospective cohort study. GMs were scored according to a semiquantitative scoring system: the GMs optimality score (GMOS) at preterm and term ages. Brain magnetic resonance imaging (MRI) at term-equivalent age was scored using a validated scoring system (MRI score). We examined the relationship between the two scores by multiple regression analysis with relevant clinical background.
We included 50 very-low-birth-weight infants cared for at Oita University Hospital from August 2012 to August 2018 who underwent MRI and GMs assessment. Their median gestational age and birth weight were 29w2d and 1145 g, respectively.
The MRI score and systemic steroid administration were related to preterm GMOS, and the MRI score was related to term GMOS. The component cerebellum score and cortical grey matter score of the MRI score were associated with preterm GMOS, and the cerebellum and the cerebral white matter scores were associated with term GMOS.
The quality of GMs was associated with brain morphological development. The co-evaluation of GMs and brain morphology leads to accurate developmental prediction.
阐明脑的形态学特征，其是极低出生体重儿一般运动（GMs）出现的基础。
前瞻性队列研究。GMs根据半定量评分系统进行评分：早产和足月时的GMs最优性评分（GMOS）。足月等效年龄时的脑磁共振成像（MRI）使用经过验证的评分系统（MRI评分）进行评分。我们通过多元回归分析及相关临床背景来研究这两个评分之间的关系。
我们纳入了2012年8月至2018年8月在大分大学医院接受治疗的50例极低出生体重儿，这些患儿均接受了MRI和GMs评估。他们的中位胎龄和出生体重分别为29周2天和1145克。
MRI评分和全身使用类固醇与早产GMOS相关，MRI评分与足月GMOS相关。MRI评分中的小脑成分评分和皮质灰质评分与早产GMOS相关，小脑和脑白质评分与足月GMOS相关。
GMs的质量与脑形态发育相关。GMs和脑形态的联合评估有助于准确的发育预测。
