一般和腹部肥胖与帕金森病风险：一项前瞻性队列研究。
General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study.
机构信息
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Germany.
Department of Pharmacology and Clinical Neuroscience, Department of Biobank Research, Umeå University, Sweden.
出版信息
Parkinsonism Relat Disord. 2019 May;62:98-104. doi: 10.1016/j.parkreldis.2019.01.019. Epub 2019 Feb 8.
INTRODUCTION
Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.
METHODS
In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Cox proportional hazards regression was used to calculate hazard ratios (HR) with 95% confidence intervals (CI). We modelled anthropometric variables as continuous and categorical exposures and performed subgroup analyses by potential effect modifiers including sex and smoking.
RESULTS
We found no association between BMI, WC and incident PD, neither among men nor among women. Among never and former smokers, BMI and waist circumference were also not associated with PD risk. For male smokers, however, we observed a statistically significant inverse association between BMI and PD risk (HR 0.51, 95%CI: 0.30, 0.84) and the opposite for women, i.e. a significant direct association of BMI (HR 1.79, 95%CI: 1.04, 3.08) and waist circumference (HR 1.64, 95%CI: 1.03, 2.61) with risk of PD.
CONCLUSION
Our data revealed no association between excess weight and PD risk but a possible interaction between anthropometry, sex and smoking.
简介
由于人口结构的变化，预计未来帕金森病（PD）患者的发病率将会增加，因此迫切需要确定可改变的危险因素。我们旨在研究体重指数（BMI）和腰围（WC）与 PD 发病的相关性。
方法
在欧洲前瞻性癌症与营养研究（EPIC）的 23 个中心中的 13 个中心，在 1992 年至 2012 年期间共确定了 734 例 PD 新发病例，平均随访时间为 12 年。使用 Cox 比例风险回归计算风险比（HR）及其 95%置信区间（CI）。我们将人体测量变量建模为连续和分类暴露，并进行了包括性别和吸烟在内的潜在效应修饰剂的亚组分析。
结果
我们没有发现 BMI 和 WC 与 PD 发病之间存在关联，无论在男性还是女性中都是如此。在从不吸烟者和前吸烟者中，BMI 和腰围与 PD 风险也没有关联。然而，对于男性吸烟者，我们观察到 BMI 与 PD 风险呈显著负相关（HR 0.51，95%CI：0.30，0.84），而女性则相反，即 BMI（HR 1.79，95%CI：1.04，3.08）和腰围（HR 1.64，95%CI：1.03，2.61）与 PD 风险呈显著正相关。
结论
我们的数据显示，超重与 PD 风险之间没有关联，但人体测量、性别和吸烟之间可能存在相互作用。
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