在着床后，膳食暴露于真菌毒素玉米赤霉烯酮（ZEA）会对小鼠胎盘发育产生不利影响。
Dietary exposure to mycotoxin zearalenone (ZEA) during post-implantation adversely affects placental development in mice.
机构信息
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA, USA; Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences (NIEHS/NIH), 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA, USA.
出版信息
Reprod Toxicol. 2019 Apr;85:42-50. doi: 10.1016/j.reprotox.2019.01.010. Epub 2019 Feb 14.
Zearalenone (ZEA) is a common food contaminant (ppb-ppm) derived from Fusarium fungi. With its estrogenicity and potential chronic exposure, ZEA poses a risk to pregnancy. Our previous studies implied post-implantational lethality by ZEA. Since a functional placenta is essential for fetal development and survival, it was hypothesized that ZEA may have adverse effects on placental development leading to post-implantational lethality. Exposure of young mice to 0, 0.8, 4, 10, and 40 ppm ZEA diets from gestation day 5.5 (D5.5) to D13.5 led to increased resorption of implantation sites, increased placental hemorrhage, decreased placental and fetal weights, proportionally reduced placental layers, and disorganized placental labyrinth vascular spaces in the 40 ppm ZEA group, as well as lipid accumulation in the labyrinth layer of all four ZEA treatment groups examined on D13.5. These data demonstrate adverse effects of ZEA on placental development.
玉米赤霉烯酮（ZEA）是一种常见的食品污染物（ppb-ppm），来源于镰刀菌真菌。由于其雌激素特性和潜在的慢性暴露，ZEA 对妊娠构成风险。我们之前的研究表明 ZEA 具有植入后致死性。由于功能性胎盘对于胎儿发育和生存至关重要，因此假设 ZEA 可能对胎盘发育产生不利影响，导致植入后致死。从妊娠第 5.5 天（D5.5）到第 13.5 天，年轻小鼠暴露于 0、0.8、4、10 和 40 ppm 的 ZEA 饮食中，导致着床部位吸收率增加、胎盘出血增加、胎盘和胎儿重量减轻、胎盘层比例减少以及 40 ppm ZEA 组的胎盘迷路血管空间排列紊乱，以及在 D13.5 时检查的所有四个 ZEA 处理组的迷路层中的脂质积累。这些数据表明 ZEA 对胎盘发育有不良影响。
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