Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China; State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Institute of Water Sciences, College of Engineering, Peking University, Beijing 100871, China.
Ecotoxicol Environ Saf. 2019 May 30;173:192-202. doi: 10.1016/j.ecoenv.2019.01.114. Epub 2019 Feb 14.
Bisphenol S (BPS) has been introduced into the industry as a safer alternative to bisphenol A (BPA). The distribution of BPS has recently become an important issue worldwide, but investigations on the toxicity and mechanisms of BPS remain limited. A review of the literature reveals that BPS has widespread presence in environmental media, such as indoor dust, surface water, sediments, and sewage sludge. It has been detected in plants, paper products, some food items, and even in the human body. In addition, compared to BPA, BPS has a lower acute toxicity, similar or less endocrine disruption, similar neurotoxicity and immunotoxicity, and lower reproductive and developmental toxicity. The mechanisms underlying BPS toxicity may be related to the chemical properties of BPS in the human body, including interactions with estrogen receptors, and binding to DNA and some proteins, subsequently including exerting oxidative stress. However, further investigation on the potential risks of BPS to humans and its mechanisms of toxicity should be conducted to better understand and control the risks of such novel chemicals.
双酚 S（BPS）作为双酚 A（BPA）的替代品被引入工业界。BPS 的分布最近成为全球的一个重要问题，但对 BPS 的毒性和作用机制的研究仍然有限。文献综述表明，BPS 广泛存在于环境介质中，如室内灰尘、地表水、沉积物和污水污泥。它已在植物、纸制品、一些食品甚至人体内被检测到。此外，与 BPA 相比，BPS 的急性毒性较低，内分泌干扰作用相似或更小，神经毒性和免疫毒性相似，生殖和发育毒性较低。BPS 毒性的作用机制可能与其在人体内的化学性质有关，包括与雌激素受体的相互作用，以及与 DNA 和一些蛋白质的结合，进而包括氧化应激的产生。然而，为了更好地了解和控制这些新型化学物质的风险，应该对 BPS 对人类的潜在风险及其毒性作用机制进行进一步研究。
