Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6200 MD, Maastricht, the Netherlands.
Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Diabetologia. 2019 Jun;62(6):888-899. doi: 10.1007/s00125-019-4831-3. Epub 2019 Feb 16.
NAD has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, NAD has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the NAD/SIRT axis have triggered an increased interest in NAD as an enhancer of energy metabolism. As a result, a myriad of publications have focused on NAD metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing NAD metabolism in humans and to set the stage for what the future of this exciting field may hold.
自 20 世纪初发现 NAD 以来，它在科学界已经多次流行和衰落。在过去的十年中，NAD 作为一种对抗代谢紊乱和通过 SIRT 酶介导的线粒体功能障碍的潜在靶点而出现。NAD/SIRT 轴的有益代谢作用引发了人们对 NAD 作为能量代谢增强剂的兴趣增加。因此，大量出版物集中在 NAD 代谢上，其中大部分工作是使用体外模型进行的，而体内工作主要包括秀丽隐杆线虫和啮齿动物的干预。另一方面，人类干预试验很少。本文的目的是概述影响人类 NAD 代谢的最新技术，并为这个令人兴奋的领域的未来奠定基础。
