Castro A P G, Ruben R B, Gonçalves S B, Pinheiro J, Guedes J M, Fernandes P R
a IDMEC, Instituto Superior Técnico , Universidade de Lisboa , Lisbon , Portugal.
b ESTG, CDRSP , Polytechnic Institute of Leiria , Leiria , Portugal.
Comput Methods Biomech Biomed Engin. 2019 May;22(6):567-573. doi: 10.1080/10255842.2019.1569638. Epub 2019 Feb 18.
The combination of computational methods with 3D printing allows for the control of scaffolds microstructure. Lately, triply periodic minimal surfaces (TPMS) have been used to design porosity-controlled scaffolds for bone tissue engineering (TE). The goal of this work was to assess the mechanical properties of TPMS Gyroid structures with two porosity levels (50 and 70%). The scaffold stiffness function of porosity was determined by the asymptotic homogenisation method and confirmed by mechanical testing. Additionally, microCT analysis confirmed the quality of the printed parts. Thus, the potential of both design and manufacturing processes for bone TE applications is here demonstrated.
计算方法与3D打印相结合能够实现对支架微观结构的控制。最近，三重周期极小曲面（TPMS）已被用于设计用于骨组织工程（TE）的孔隙率可控支架。这项工作的目的是评估具有两种孔隙率水平（50%和70%）的TPMS类螺旋结构的力学性能。通过渐近均匀化方法确定了孔隙率的支架刚度函数，并通过力学测试进行了验证。此外，显微CT分析证实了打印部件的质量。因此，本文展示了骨组织工程应用的设计和制造工艺的潜力。
