School of Distance Education, Universiti Sains Malaysia, Penang, Malaysia.
School of Chemical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Nat Prod Res. 2020 Dec;34(23):3404-3408. doi: 10.1080/14786419.2019.1569012. Epub 2019 Feb 17.
L., locally known as "" in Malaysia is widely used in folkloric medicine to treat various diseases. The present study was aimed to examine the chemical composition of the essential oil from the leaves of L. (EO-GC) and its cytotoxic and antimicrobial potential. EO-GC obtained by hydrodistillation was analysed using capillary GC and GC-MS. Twenty-two compounds were identified, dominated by -copaene (61.25%), germacrene D (6.72%) and -caryophyllene (5.85%). In the MTT assay, EO-GC exhibited significant anti-proliferative effects towards MCF-7 human breast cancer cells with IC value of 45.2 μg/mL. Regarding the antimicrobial activity, it showed better inhibitory effects on Gram-positive bacteria than Gram-negative bacteria and none on the fungi and yeasts tested.
在马来西亚,L. 俗称“”,被广泛应用于民间医学以治疗各种疾病。本研究旨在研究来自 L. 叶子的精油(EO-GC)的化学成分及其细胞毒性和抗菌潜力。通过水蒸馏获得的 EO-GC 采用毛细 GC 和 GC-MS 进行分析。鉴定出 22 种化合物,主要为 β-古巴烯(61.25%)、大根香叶烯 D(6.72%)和 β-石竹烯(5.85%)。在 MTT 测定中,EO-GC 对 MCF-7 人乳腺癌细胞表现出显著的增殖抑制作用,IC 值为 45.2 μg/mL。关于抗菌活性,它对革兰氏阳性菌的抑制作用优于革兰氏阴性菌,对测试的真菌和酵母菌均无抑制作用。