Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil.
Núcleo de Pesquisa de Produtos Naturais, Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Nat Prod Res. 2024 Oct;38(19):3449-3453. doi: 10.1080/14786419.2023.2245957. Epub 2023 Aug 15.
(L.) R. Br. (Lamiaceae) is a naturalised medicinal plant in Brazil known as 'cordão-de-frade', being used in folk medicine for the treatment of a variety of conditions such as infections and inflammations. leaf and flower essential oils were isolated by hydrodistillation, and their compounds were identified by GC-MS analysis. The leaf essential oil major constituents were germacrene D (31.5%), and β-caryophyllene (19.2%), while in flower essential oil the main constituents were β-elemene (31.2%), and germacrene D (12.1%). The essential oils were investigated against a broad spectrum of bacteria and fungi using the microdilution method, exhibiting MIC values of 3.93-250 µg mL. Both oils showed excellent antifungal properties, which is a very important finding since most fungi have shown increased resistance to known antifungal agents. According to these results, the essential oils of are promising sources of new antimicrobial agents, especially for yeast.
唇形科（Lamiaceae）植物罗勒（L. R. Br.）是巴西的一种归化药用植物，俗称“cordão-de-frade”，民间医学用于治疗多种疾病，如感染和炎症。通过水蒸馏法分离其叶和花的精油，并通过 GC-MS 分析鉴定其化合物。叶精油的主要成分是反式-金合欢烯 D（31.5%）和β-石竹烯（19.2%），而花精油的主要成分是β-榄香烯（31.2%）和反式-金合欢烯 D（12.1%）。采用微量稀释法研究了精油对广谱细菌和真菌的抑制作用，其 MIC 值为 3.93-250μg·mL。两种精油均表现出优异的抗真菌特性，这是一个非常重要的发现，因为大多数真菌对已知的抗真菌药物的耐药性都有所增加。根据这些结果，罗勒精油是有前途的新型抗菌剂来源，特别是针对酵母。
