School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
J Eval Clin Pract. 2020 Feb;26(1):242-247. doi: 10.1111/jep.13108. Epub 2019 Feb 17.
An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated.
Data from 16 526 men and 18 438 women, aged 21 to 30 years, were collected from a national database. Individuals were separated into the AR and non-AR groups. Eight common DDs were studied: (1) gastroesophageal reflux disease (GERD), (2) gastritis and duodenitis, (3) peptic ulcers, (4) irritable bowel syndrome, (5) gastric functional disease, (6) intestinal functional disease, (7) gastroenteritis and colitis, and (8) constipation. The rate of each DD was compared between groups. In individuals with specific DDs, the frequency of clinical visits for each DD was also compared between groups. Between users and nonusers of topical steroids in the AR group, the rate of DDs was compared.
Significant associations were observed between all eight DDs and AR in both sexes. In comparison to the non-AR group, women with AR visited clinics more frequently for gastritis/duodenitis, gastric and intestinal functional disease, gastroenteritis/colitis, and constipation, while men with AR visited clinics more frequently for gastritis/duodenitis, gastric functional disease, gastroenteritis/colitis, and constipation. Female topical-steroid users with AR had higher rates of GERD, irritable bowel syndrome, gastric or intestinal functional disease, and gastritis/colitis. Male topical-steroid users with AR had higher rates of GERD and peptic ulcers.
AR was associated with DDs in both sexes. However, the influence of AR on clinical visit frequency varied among specific DD groups. Topical steroid usage for AR was associated with some DDs, but the association requires future evaluation.
已经有报道称过敏性鼻炎（AR）与消化系统疾病（DDs）之间存在关联；然而，这些研究仅关注 AR 患者群体中 DDs 的患病率。在患有特定 DDs 的个体中，AR 对每种 DD 就诊频率的影响尚未得到研究。此外，AR 局部用皮质类固醇的使用与 DDs 之间的关联也尚未被调查。
从一个全国性数据库中收集了 16526 名男性和 18438 名女性（年龄 21 至 30 岁）的数据。将个体分为 AR 组和非 AR 组。研究了八种常见的 DDs：（1）胃食管反流病（GERD）；（2）胃炎和十二指肠炎；（3）消化性溃疡；（4）肠易激综合征；（5）胃功能性疾病；（6）肠功能性疾病；（7）胃肠炎和结肠炎；（8）便秘。比较两组之间每种 DD 的发生率。在患有特定 DDs 的个体中，还比较了两组之间每种 DD 的就诊频率。比较了 AR 组中局部用皮质类固醇使用者和非使用者之间的 DD 发生率。
在男女两性中，所有八种 DDs 与 AR 均存在显著关联。与非 AR 组相比，患有 AR 的女性因胃炎/十二指肠炎、胃和肠功能性疾病、胃肠炎/结肠炎和便秘而就诊的频率更高，而患有 AR 的男性因胃炎/十二指肠炎、胃功能性疾病、胃肠炎/结肠炎和便秘而就诊的频率更高。患有 AR 的女性局部用皮质类固醇使用者的 GERD、肠易激综合征、胃或肠功能性疾病以及胃炎/结肠炎的发生率更高。患有 AR 的男性局部用皮质类固醇使用者的 GERD 和消化性溃疡的发生率更高。
AR 在两性中均与 DDs 相关。然而，AR 对特定 DD 组就诊频率的影响存在差异。AR 局部用皮质类固醇的使用与某些 DD 相关，但这种关联需要进一步评估。
