Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan.
Department of Nursing, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan.
Sci Rep. 2019 Oct 29;9(1):15535. doi: 10.1038/s41598-019-51661-4.
Gastroesophageal reflux disease (GERD) can cause several upper airway symptoms and alter the physiology of nasopharyngeal mucosa, while upper airway diseases in turn might also exacerbate GERD symptoms. For a long time, asthma was considered a risk factor of GERD in the literature. Asthma and allergic rhinitis (AR) are usually identified as united airway disease according to similar epidemiology and pathophysiology; however, the association between AR and GERD is less elucidated. We aimed to evaluate whether AR would increase the development of GERD. Patients diagnosed as AR were identified from the National Health Insurance Research Database between January 1, 2000 and December 31, 2005 without prior history of gastroesophageal reflux disease. The outcome of interest was new-onset GERD. Cox regression models were applied to calculate the hazard ratio (HR) of GERD. We analyzed the data of 193,810 AR patients aged 18 years or older and being free of AR at baseline. The AR cohort (n = 96,905) had a significantly increased risk of GERD over a non-AR cohort (n = 96905) (adjusted HR (aHR) 1.94; 95% CI = 1.88-1.99, p < 0.001). AR may have stronger correlation with GERD than does asthma, although asthma might increase GERD risk by means of certain pathways shared with AR.
胃食管反流病（GERD）可引起多种上呼吸道症状，并改变鼻咽黏膜的生理学特性，而上呼吸道疾病反过来也可能加重 GERD 症状。长期以来，哮喘一直被认为是文献中 GERD 的一个危险因素。哮喘和过敏性鼻炎（AR）通常根据相似的流行病学和病理生理学被认为是联合气道疾病；然而，AR 和 GERD 之间的关联尚未阐明。我们旨在评估 AR 是否会增加 GERD 的发生。从 2000 年 1 月 1 日至 2005 年 12 月 31 日，从国家健康保险研究数据库中确定了诊断为 AR 的患者，且这些患者没有 GERD 的既往病史。感兴趣的结果是新发生的 GERD。Cox 回归模型用于计算 GERD 的风险比（HR）。我们分析了 193810 名年龄在 18 岁或以上且基线时无 AR 的 AR 患者的数据。AR 队列（n=96905）发生 GERD 的风险明显高于非 AR 队列（n=96905）（调整后的 HR（aHR）为 1.94；95%CI=1.88-1.99，p<0.001）。尽管哮喘可能通过与 AR 共享的某些途径增加 GERD 风险，但 AR 与 GERD 的相关性可能比哮喘更强。
