miR-124，一种结直肠癌潜在的治疗靶点。
miR-124, a potential therapeutic target in colorectal cancer.
作者信息
Qin Zhen, Liu Xia
机构信息
Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,
出版信息
Onco Targets Ther. 2019 Jan 22;12:749-751. doi: 10.2147/OTT.S179501. eCollection 2019.
Recently, miR-124 has been regarded as a critical modulator of colorectal cancer. We here summarize the studies on the role and mechanism of miR-124 in colorectal cancer. They indicate that miR-124 is methylated during carcinogenesis and functions as a tumor-suppressor in colorectal cancer. miR-124 might serve as a potential diagnostic biomarker and therapeutic target in colorectal cancer in the foreseeable future.
最近，miR-124被认为是结直肠癌的关键调节因子。我们在此总结了关于miR-124在结直肠癌中的作用和机制的研究。这些研究表明，miR-124在致癌过程中发生甲基化，并在结直肠癌中发挥肿瘤抑制作用。在可预见的未来，miR-124可能作为结直肠癌潜在的诊断生物标志物和治疗靶点。
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