微小RNA（miR）-124：肿瘤学中一个有前景的治疗切入点
MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology.
作者信息
Gourishetti Karthik, Balaji Easwaran Vignesh, Mostakim Youssef, Ranganath Pai K Sreedhara, Bhere Deepak
机构信息
Biotherapeutics Laboratory, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA.
Department of Pathology, Microbiology, and Immunology, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA.
出版信息
Biology (Basel). 2023 Jun 28;12(7):922. doi: 10.3390/biology12070922.
MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.
微小RNA（miR）是一类参与转录后基因调控的小型非编码RNA。miR表达的改变与多种病理状况相关。微小RNA - 124（miR - 124）是在脑以及胸腺、淋巴结、骨髓和外周血单核细胞中大量表达的miR。它在宿主免疫系统的调节中起关键作用。新兴研究表明，miR - 124表达失调是几种癌症类型的一个标志，并且它被认为与这些恶性肿瘤的进展有关。在本综述中，我们全面总结了miR - 124作为肿瘤学中一个有前景的治疗切入点的作用。
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