从异常生物合成、转运和清除角度看环状RNA在癌症中的失调
Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal.
作者信息
Wu Qiongqiong, Li Peiyao, Wu Minghua, Liu Qiang
机构信息
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, China.
Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China.
出版信息
Front Genet. 2019 Feb 1;10:16. doi: 10.3389/fgene.2019.00016. eCollection 2019.
CircRNAs (circular RNAs) are a class of RNAs generated from circularization with multiple novel functions. Recent studies have revealed the aberrant expression and aberrant functions of circRNAs in various tumors; thus, circRNAs have been recognized as promising cancer biomarkers. However, the underlying mechanisms behind their aberrant expression and functions remain unclear. In this review, we discuss at length the cancer-specific deregulation of circRNAs and the potential underlying aberrant events in circRNA biogenesis, localization and removal in cancer cells.
环状RNA（circRNAs）是一类通过环化产生的具有多种新功能的RNA。最近的研究揭示了circRNAs在各种肿瘤中的异常表达和异常功能；因此，circRNAs已被认为是有前景的癌症生物标志物。然而，其异常表达和功能背后的潜在机制仍不清楚。在这篇综述中，我们详细讨论了circRNAs在癌症中的特异性失调以及癌细胞中circRNA生物合成、定位和清除过程中潜在的异常事件。
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