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树皮可改善角叉菜胶诱导的大鼠炎症模型和弗氏佐剂诱导的大鼠关节炎模型中的炎症和关节炎。

Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund's Adjuvant-Induced Arthritis Model in Rats.

作者信息

Jitta Srinivasa Reddy, Daram Prasanthi, Gourishetti Karthik, Misra C S, Polu Picheswara Rao, Shah Abhishek, Shreedhara C S, Nampoothiri Madhavan, Lobo Richard

机构信息

Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

出版信息

J Toxicol. 2019 Jan 17;2019:7898914. doi: 10.1155/2019/7898914. eCollection 2019.

DOI:10.1155/2019/7898914
PMID:30774656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6354132/
Abstract

bark belongs to the family Combretaceae. The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of bark confirms the presence of flavonoids, polyphenols, and tannins. The plant has not been investigated for its anti-inflammatory and antiarthritic activity. The present study was undertaken to explore its possible anti-inflammatory and antiarthritic activity. Anti-inflammatory activity of alcoholic and aqueous extracts of the bark was assessed by methods. antiarthritic potential of the extracts was evaluated by Complete Freund's Adjuvant (CFA) induced arthritis in Wistar rats. Our findings showed that the alcoholic and aqueous extracts exhibited anti-inflammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch inflammation models. We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund's Adjuvant-induced arthritis in Wistar rats. This study shows that the bark extracts possess anti-inflammatory activity and have pronounced effects on adjuvant arthritis also. Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-inflammatory and antiarthritic activity of .

摘要

树皮属于使君子科。该植物树皮具有收敛性，可用于治疗溃疡、瓦塔病（一种中医病症概念，可意译为风症）、骨折、出血、支气管炎和腹泻。对树皮的植物化学研究证实了黄酮类化合物、多酚和单宁的存在。尚未对该植物的抗炎和抗关节炎活性进行研究。本研究旨在探索其可能的抗炎和抗关节炎活性。通过多种方法评估了树皮乙醇提取物和水提取物的抗炎活性。通过完全弗氏佐剂（CFA）诱导Wistar大鼠患关节炎来评估提取物的抗关节炎潜力。我们的研究结果表明，在角叉菜胶诱导的后爪水肿和角叉菜胶诱导的气囊炎症模型中，乙醇提取物和水提取物在口服剂量500mg/kg时均表现出抗炎活性。我们还发现，树皮的乙醇提取物和水提取物恢复了由完全弗氏佐剂诱导Wistar大鼠患关节炎所导致的血液和血清参数的改变。这项研究表明，树皮提取物具有抗炎活性，对佐剂性关节炎也有显著作用。未来有必要进行进一步研究，以更深入地了解其抗炎和抗关节炎活性的确切作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/e79bb264cfbe/JT2019-7898914.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/defdd21957d9/JT2019-7898914.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/fba7475762b4/JT2019-7898914.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/724560db226a/JT2019-7898914.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/0ee14bed2045/JT2019-7898914.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/23fb78174987/JT2019-7898914.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/005a3df96ec6/JT2019-7898914.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/e79bb264cfbe/JT2019-7898914.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/defdd21957d9/JT2019-7898914.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/fba7475762b4/JT2019-7898914.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/724560db226a/JT2019-7898914.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/0ee14bed2045/JT2019-7898914.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/23fb78174987/JT2019-7898914.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/005a3df96ec6/JT2019-7898914.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/6354132/e79bb264cfbe/JT2019-7898914.007.jpg

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