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The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms.年龄对 1 型糖尿病进展和严重程度的影响：对疾病机制的潜在影响。
Curr Diab Rep. 2018 Sep 26;18(11):115. doi: 10.1007/s11892-018-1083-4.
2
Self-reported color-race and genomic ancestry in an admixed population: A contribution of a nationwide survey in patients with type 1 diabetes in Brazil.在混合人群中自我报告的肤色和基因组血统：巴西 1 型糖尿病患者全国调查的贡献。
Diabetes Res Clin Pract. 2018 Jun;140:245-252. doi: 10.1016/j.diabres.2018.03.021. Epub 2018 Mar 21.
3
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.遗传风险评分在多种族 1 型糖尿病人群中的应用表明风险建模需要多样性。
Sci Rep. 2018 Mar 14;8(1):4529. doi: 10.1038/s41598-018-22574-5.
4
The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.6 号染色体 q22.33 区域与 1 型糖尿病的发病年龄和 5 岁以下确诊患者的疾病风险相关。
Diabetologia. 2018 Jan;61(1):147-157. doi: 10.1007/s00125-017-4440-y. Epub 2017 Oct 5.
5
Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes.白细胞介素-18 和白细胞介素-12B 基因多态性与克罗地亚 1 型糖尿病患者临床结局的关系。
Gene. 2013 Jan 10;512(2):477-81. doi: 10.1016/j.gene.2012.10.029. Epub 2012 Nov 6.
6
Prevalence of adults with type 1 diabetes who meet the goals of care in daily clinical practice: a nationwide multicenter study in Brazil.巴西全国多中心研究：日常临床实践中达到治疗目标的 1 型糖尿病成人患者的患病率。
Diabetes Res Clin Pract. 2012 Jul;97(1):63-70. doi: 10.1016/j.diabres.2012.02.008. Epub 2012 Mar 6.
7
Effects of insulin and glucose on cytokine production from peripheral blood mononuclear cells.胰岛素和葡萄糖对外周血单个核细胞细胞因子产生的影响。
Chang Gung Med J. 2008 May-Jun;31(3):253-9.
8
Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.白细胞介素-12与白细胞介素-18在干扰素-γ基因表达方面的协同作用：白细胞介素-12诱导的信号转导和转录激活因子4通过上调白细胞介素-18诱导的激活蛋白1的结合活性促进干扰素-γ启动子激活。
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Interleukin 12 and autoimmune diabetes.白细胞介素12与自身免疫性糖尿病
Nat Genet. 2001 Feb;27(2):131-2. doi: 10.1038/84732.

基因多态性影响非洲裔巴西人1型糖尿病的发病年龄。

Gene Polymorphism Influences Age of Onset of DM1 in African Ancestry Brazilians.

作者信息

Boëchat-Fernandes Alejandro, Réa Rosângela Roginski, Romanzini Nicole Balster, Gomes Marilia Brito, Furtado-Alle Lupe, Souza Ricardo L R

机构信息

Department of Genetics, Federal University of Paraná, Curitiba, Paraná, Brazil.

Endocrinology and Metabolism Service, University Hospital of the Federal University of Paraná, Curitiba, Paraná, Brazil.

出版信息

J Pediatr Genet. 2019 Mar;8(1):38-40. doi: 10.1055/s-0039-1677749. Epub 2019 Jan 30.

DOI:10.1055/s-0039-1677749
PMID:30775053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6375717/
Abstract

The aim of this study was to investigate the relationship of two single nucleotide polymorphisms (SNPs) in the interleukin-18 ( ) gene (rs187238, g.-137G > C; rs1946518, g.-607C > A) and one SNP of the gene (rs3212227 g.*159A > C, 3'UTR) with the age of onset for type 1 (DM1). A total of 1,101 patients with DM1 enrolled in 13 centers from different regions of Brazil were genotyped with TaqMan assay and classified according to the ancestry. Our results show that an SNP in gene could be associated with DM1 age onset, taking into account that this studied variation affects gene expression.

摘要

本研究旨在调查白细胞介素-18（IL-18）基因中的两个单核苷酸多态性（SNP）（rs187238，g.-137G＞C；rs1946518，g.-607C＞A）以及IL-18基因的一个SNP（rs3212227 g.*159A＞C，3'非翻译区）与1型糖尿病（DM1）发病年龄的关系。对来自巴西不同地区13个中心的1101例DM1患者进行了TaqMan检测基因分型，并根据血统进行分类。我们的结果表明，考虑到所研究的变异会影响基因表达，IL-18基因中的一个SNP可能与DM1发病年龄有关。