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How gut microbes are joining the fight against cancer.肠道微生物如何加入抗癌斗争。
Nature. 2018 May;557(7706):482-484. doi: 10.1038/d41586-018-05208-8.
2
Endoscopic Screening in Asian Countries Is Associated With Reduced Gastric Cancer Mortality: A Meta-analysis and Systematic Review.亚洲国家的内镜筛查与胃癌死亡率降低相关:一项荟萃分析和系统评价。
Gastroenterology. 2018 Aug;155(2):347-354.e9. doi: 10.1053/j.gastro.2018.04.026. Epub 2018 Apr 30.
3
Environment dominates over host genetics in shaping human gut microbiota.环境在塑造人类肠道微生物群方面优于宿主遗传学。
Nature. 2018 Mar 8;555(7695):210-215. doi: 10.1038/nature25973. Epub 2018 Feb 28.
4
Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries.全球癌症生存趋势监测 2000-14 年(CONCORD-3):对来自 71 个国家 322 个基于人群的登记处的 37513025 名诊断患有 18 种癌症之一的患者的个体记录进行分析。
Lancet. 2018 Mar 17;391(10125):1023-1075. doi: 10.1016/S0140-6736(17)33326-3. Epub 2018 Jan 31.
5
Host genetic variation and its microbiome interactions within the Human Microbiome Project.人类微生物组计划中的宿主遗传变异及其与微生物组的相互作用。
Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
6
The Human Gastric Microbiome Is Predicated upon Infection with .人类胃部微生物群取决于感染…… (原文此处不完整)
Front Microbiol. 2017 Dec 14;8:2508. doi: 10.3389/fmicb.2017.02508. eCollection 2017.
7
The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer.胃微生物群、其与幽门螺杆菌的相互作用及其在胃癌进展中的潜在作用。
PLoS Pathog. 2017 Oct 5;13(10):e1006573. doi: 10.1371/journal.ppat.1006573. eCollection 2017 Oct.
8
BabA in adaptation for gastric colonization.BabA 对胃定植的适应。
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Analysis of the Viable Microbiota and Helicobacter pylori Transcriptome in Gastric Infection and Early Stages of Carcinogenesis.胃感染及癌变早期阶段中活微生物群和幽门螺杆菌转录组的分析
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10
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向胃病倾斜:宿主-病原体基因组错配?

Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch?

作者信息

Tavera Gloria, Morgan Douglas R, Williams Scott M

机构信息

Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.

Vanderbilt Ingram Cancer Center, Nashville, Tennessee.

出版信息

Curr Genet Med Rep. 2018 Dec;6(4):199-207. doi: 10.1007/s40142-018-0153-x. Epub 2018 Oct 10.

DOI:10.1007/s40142-018-0153-x
PMID:30775159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6373874/
Abstract

PURPOSE OF REVIEW

Chronic infection with infection is necessary but not sufficient to initiate development of intestinal-type gastric adenocarcinoma. It is not clear what additional factors tip the scale from commensal bacteria towards a pathogen that facilitates development of gastric cancer. Genetic variants in both the pathogen and host have been implicated, but neither alone explains a substantial portion of disease risk.

RECENT FINDINGS

In this review, we consider studies that address the important role of human and bacterial genetics, ancestry and their interactions in determining gastric disease risk. We observe gaps in the current literature that should guide future work to confirm the hypothesis of the interacting roles of host and bacterial genetics that will be necessary to translate these findings into clinically relevant information.

SUMMARY

We summarize genetic risk factors for gastric disease in both and human hosts. However, genetic variation of one or the other organism in isolation insufficiently explains gastric disease risk. The most promising models of gastric disease risk simultaneously consider the genetic variation of both the and human host, under a co-evolution model.

摘要

综述目的

幽门螺杆菌慢性感染是肠型胃腺癌发生发展的必要但非充分条件。尚不清楚哪些额外因素会使共生菌转变为促进胃癌发生的病原体。病原体和宿主的基因变异都与之相关,但单独任何一方都不能解释很大一部分疾病风险。

最新发现

在本综述中,我们考量了一些研究,这些研究探讨了人类和细菌遗传学、血统及其相互作用在决定胃部疾病风险方面的重要作用。我们发现当前文献中存在空白,这些空白应指导未来的研究工作,以证实宿主和细菌遗传学相互作用的假说,而这对于将这些发现转化为临床相关信息是必要的。

总结

我们总结了幽门螺杆菌和人类宿主中胃部疾病的遗传风险因素。然而,单独一种生物体的基因变异不足以解释胃部疾病风险。在共同进化模型下,最有前景的胃部疾病风险模型同时考虑幽门螺杆菌和人类宿主的基因变异。