基于网络的欧洲四国大学生常见精神障碍针对性预防——一项随机对照试验的研究方案
Web-based indicated prevention of common mental disorders in university students in four European countries - Study protocol for a randomised controlled trial.
作者信息
Musiat Peter, Potterton Rachel, Gordon Gemma, Spencer Lucy, Zeiler Michael, Waldherr Karin, Kuso Stefanie, Nitsch Martina, Adamcik Tanja, Wagner Gudrun, Karwautz Andreas, Ebert David Daniel, Dodd Alyson, Dooley Barbara, Harrison Amy, Whitt Emma, Haselgrove Mark, Sharpe Helen, Smith Jo, Tressler Rosie, Troop Nicholas, Vinyard Chantal, Görlich Dennis, Beecham Jenny, Bonin Eva, Jacobi Corinna, Schmidt Ulrike
机构信息
King's College London, Institute of Psychiatry, Psychology and Neuroscience, Section of Eating Disorders, PO59, 16 De Crespigny Park, London SE5 8AF, United Kingdom.
Medical University of Vienna, Department for Child and Adolescent Psychiatry, Eating Disorders Unit, Spitalgasse 23, 1090 Vienna, Austria.
出版信息
Internet Interv. 2018 Mar 15;16:35-42. doi: 10.1016/j.invent.2018.02.004. eCollection 2019 Apr.
BACKGROUND
Mental disorders and their symptoms are highly prevalent in the university student population, and the transition from secondary to tertiary education is associated with a rise in mental health problems. Existing web-based interventions for the prevention of common mental disorders in student populations often focus on just one disorder and have not been designed specifically for students. There is thus a need for transdiagnostic, student-specific preventative interventions that can be widely disseminated. This two-arm, parallel group randomised controlled trial aims to evaluate the effectiveness and cost-effectiveness of a web-based transdiagnostic mental health problem prevention programme (PLUS) across several universities in four countries.
METHOD
Students ( = 5550) will be recruited through a variety of channels and asked to complete a personality assessment to determine whether they are at high risk for developing common mental disorders. Students at high risk will be randomly allocated to either PLUS or a control intervention, which provides practical support around issues commonly experienced at university. Students at low risk will be allocated to the control intervention. Both intervention groups will be assessed at baseline, 4 weeks, 3 months, 6 months and 12 months after randomisation. Depression and generalised anxiety, assessed using the Patient Health Questionnaire and the Generalised Anxiety Disorder scales, will form the primary outcomes in this study. Secondary outcome measures include alcohol and drug use, eating behaviour, self-esteem, and quality of life. The cost-effectiveness of the intervention will also be evaluated.
CONCLUSIONS
This study will contribute to understanding the role of transdiagnostic indicated web-based interventions for the prevention of common mental disorders in university students. It will also be one of the first studies to investigate the cost-effectiveness of such interventions.
TRIAL REGISTRATION
This trial was registered in the ISRCTN register (ISRCTN15570935) on 12th February 2016.
背景
精神障碍及其症状在大学生群体中极为普遍，从中学到高等教育的过渡与心理健康问题的增加有关。现有的基于网络的预防学生群体常见精神障碍的干预措施往往只关注一种障碍，且并非专门为学生设计。因此，需要能够广泛传播的针对学生的跨诊断预防性干预措施。这项双臂、平行组随机对照试验旨在评估一项基于网络的跨诊断心理健康问题预防计划（PLUS）在四个国家的几所大学中的有效性和成本效益。
方法
将通过多种渠道招募学生（n = 5550），并要求他们完成一项人格评估，以确定他们是否有患常见精神障碍的高风险。高风险学生将被随机分配到PLUS组或对照干预组，对照干预组围绕大学中常见的问题提供实际支持。低风险学生将被分配到对照干预组。两个干预组将在随机分组后的基线、4周、3个月、6个月和12个月进行评估。使用患者健康问卷和广泛性焦虑症量表评估的抑郁和广泛性焦虑将构成本研究的主要结局。次要结局指标包括酒精和药物使用、饮食行为、自尊和生活质量。还将评估干预措施的成本效益。
结论
本研究将有助于理解基于网络的跨诊断针对性干预措施在预防大学生常见精神障碍中的作用。它也将是首批调查此类干预措施成本效益的研究之一。
试验注册
本试验于2016年2月12日在ISRCTN注册库（ISRCTN15570935）注册。
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