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肺组织胞浆菌病:一种隐匿的疾病。

Pulmonary histoplasmoma: a disguised malady.

作者信息

de Matos Paulo Marcelo Pontes Gomes, Felipe-Silva Aloisio, Otoch José Pinhata

机构信息

Universidade de São Paulo, School of Medicine Internal, Medicine Department. São Paulo, SP, Brazil.

Universidade de São Paulo, School of Medicine, Department of Pathology. São Paulo, SP, Brazil.

出版信息

Autops Case Rep. 2018 Dec 5;8(4):e2018065. doi: 10.4322/acr.2018.065. eCollection 2018 Oct-Dec.

Abstract

Histoplasmosis is a mycosis caused by the dimorphic fungus, , which is transmitted via dust and aerosols. Lung involvement is the most common, with a varied clinical presentation. Although it is not the only source of infection, is frequently found in bat guano, which is the reason why it is highly prevalent among caving practitioners. The solitary histoplasmoma of the lung is an unusual and chronic manifestation of this entity, which mimics, or at least is frequently misconstrued, as a malignancy. Almost invariably, the diagnosis of this type of histoplasmosis presentation is achieved after lung biopsy. The authors present the case of a young woman who sought medical care because of chest pain. The diagnostic work-up revealed the presence of a pulmonary nodule. She was submitted to a thoracotomy and wedge pulmonary resection. The histologic analysis rendered the diagnosis of histoplasmoma. This report aims to call attention to this diagnosis as the differential diagnosis of a pulmonary nodule.

摘要

组织胞浆菌病是一种由双相真菌引起的真菌病,通过灰尘和气溶胶传播。肺部受累最为常见,临床表现多样。虽然它不是唯一的感染源,但在蝙蝠粪便中经常发现,这就是为什么它在洞穴探险者中高度流行的原因。肺孤立性组织胞浆瘤是该疾病的一种不寻常的慢性表现,它模仿,或者至少经常被误解为恶性肿瘤。几乎无一例外,这种类型的组织胞浆菌病表现的诊断是在肺活检后实现的。作者介绍了一名因胸痛寻求医疗护理的年轻女性病例。诊断检查发现有肺结节。她接受了开胸手术和肺楔形切除术。组织学分析确诊为组织胞浆瘤。本报告旨在提请注意将此诊断作为肺结节的鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cff2/6360832/c4cd9a5f8a4b/autopsy-08-04e2018065-g01.jpg

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