Kaushal Neelam, Vohora Divya, Jalali Rajinder K, Jha Sujeet
Pharmaceutical Medicine, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Medical Affairs & Clinical Research, Sun Pharmaceutical Industries Limited, Gurgaon, India.
Osteoporos Sarcopenia. 2018 Jun;4(2):53-60. doi: 10.1016/j.afos.2018.04.002. Epub 2018 May 5.
An understanding of bone mineral density (BMD) pattern in a population is crucial for prevention and diagnosis of osteoporosis and management of its complications in later life. This study aimed to screen the bone health status and factors associated with osteoporosis in an apparently healthy Indian population.
A retrospective review of medical records was done in a tertiary-care hospital for the subjects who had undergone preventive health-check-ups that included BMD measurements at femur-neck, total-femur, and lumbar-spine.
We evaluated 524 subjects (age, 50.0 ± 12.4 years) including 41.2% female and 58.8% male subjects. Osteoporosis was present in 6.9% subjects (female, 11.1%; male, 4.2%) and osteopenia in 34% subjects (female, 40.3%; male, 29.9%). Absolute BMD was higher in male subjects (P < 0.001) compared to female subjects at all bone sites. Prevalence of osteoporosis increased with age in female subjects, but not in male subjects. Osteoporosis rates in the age-groups of 30-39, 40-49, 50-59, 60-69, and ≥70 years were 3%, 3.4%, 14.3%, 18.6%, and 36.4%, respectively in female subjects while prevalence in male subjects was 0%, 4%, 6.5%, 4.3%, and 5.6%, respectively, at lumbar spine. Height (r = 0.234-0.358), weight (r = 0.305-0.388), body mass index (r = 0.143-0.285) and physical activity (r = 0.136-0.153) were positively; and alkaline phosphatase (r = -0.133 to -0.203) was negatively correlated with BMD (all P < 0.01) at all sites. These parameters retained significant correlation after controlling for age and sex. No correlation of serum 25-hydroxy-vitamin-D and calcium was noted with BMD (P > 0.05) at any site.
Further data on absolute BMD, T scores, and prevalence rates of osteoporosis/osteopenia on multiple bone sites have been presented in this article.
了解人群中的骨密度（BMD）模式对于骨质疏松症的预防、诊断以及后期并发症的管理至关重要。本研究旨在筛查印度一个看似健康的人群的骨骼健康状况以及与骨质疏松症相关的因素。
在一家三级护理医院对接受预防性健康检查的受试者的病历进行回顾性研究，这些检查包括股骨颈、全股骨和腰椎的骨密度测量。
我们评估了524名受试者（年龄50.0±12.4岁），其中女性受试者占41.2%，男性受试者占58.8%。6.9%的受试者患有骨质疏松症（女性为11.1%，男性为4.2%），34%的受试者患有骨量减少（女性为40.3%，男性为29.9%）。在所有骨部位，男性受试者的绝对骨密度均高于女性受试者（P<0.001）。女性受试者的骨质疏松症患病率随年龄增加，而男性受试者则不然。在腰椎，30 - 39岁、40 - 49岁、50 - 59岁、60 - 69岁和≥70岁年龄组的女性受试者骨质疏松症患病率分别为3%、3.4%、14.3%、18.6%和36.4%，而男性受试者的患病率分别为0%、4%、6.5%、4.3%和5.6%。身高（r = 0.234 - 0.358）、体重（r = 0.305 - 0.388）、体重指数（r = 0.143 - 0.285）和身体活动（r = 0.136 - 0.153）与所有部位的骨密度呈正相关；碱性磷酸酶（r = -0.133至 -0.203）与所有部位的骨密度呈负相关（所有P<0.01）。在控制年龄和性别后，这些参数仍保持显著相关性。在任何部位，血清25 - 羟基维生素D和钙与骨密度均无相关性（P>0.05）。
本文提供了关于多个骨部位的绝对骨密度、T值以及骨质疏松症/骨量减少患病率的进一步数据。
