• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胆碱转运体蛋白 1 促进磷脂合成：一个新兴的角色

Choline transport for phospholipid synthesis: An emerging role of choline transporter-like protein 1.

机构信息

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.

出版信息

Exp Biol Med (Maywood). 2019 May;244(8):655-662. doi: 10.1177/1535370219830997. Epub 2019 Feb 18.

DOI:10.1177/1535370219830997
PMID:30776907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6552397/
Abstract

This review will provide a summary of recent advances in choline transport research and highlight important novel areas of focus in the field.

摘要

本篇综述将对胆碱转运研究的最新进展进行总结，并重点介绍该领域的一些新的重要研究方向。

相似文献

1
Choline transport for phospholipid synthesis: An emerging role of choline transporter-like protein 1.胆碱转运体蛋白 1 促进磷脂合成：一个新兴的角色
Exp Biol Med (Maywood). 2019 May;244(8):655-662. doi: 10.1177/1535370219830997. Epub 2019 Feb 18.
2
The ubiquitous choline transporter SLC44A1.普遍存在的胆碱转运体SLC44A1。
Cent Nerv Syst Agents Med Chem. 2012 Jun;12(2):70-81. doi: 10.2174/187152412800792733.
3
Functional Expression of Choline Transporters in the Blood-Brain Barrier.血脑屏障中胆碱转运体的功能表达。
Nutrients. 2019 Sep 20;11(10):2265. doi: 10.3390/nu11102265.
4
The choline transporter-like family SLC44: properties and roles in human diseases.胆碱转运蛋白样家族 SLC44：在人类疾病中的特性和作用。
Mol Aspects Med. 2013 Apr-Jun;34(2-3):646-54. doi: 10.1016/j.mam.2012.10.011.
5
Choline transport for phospholipid synthesis.用于磷脂合成的胆碱转运
Exp Biol Med (Maywood). 2006 May;231(5):490-504. doi: 10.1177/153537020623100503.
6
Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters.胆碱转运蛋白 1 和 2 是新发现的位于细胞膜和线粒体的乙醇胺转运蛋白。
J Biol Chem. 2021 Jan-Jun;296:100604. doi: 10.1016/j.jbc.2021.100604. Epub 2021 Mar 28.
7
Choline transporter-like proteins CTLs/SLC44 family as a novel molecular target for cancer therapy.胆碱转运体样蛋白CTLs/SLC44家族作为癌症治疗的新型分子靶点。
Biopharm Drug Dispos. 2014 Nov;35(8):431-49. doi: 10.1002/bdd.1892. Epub 2014 Feb 27.
8
Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: a target molecule for lung cancer therapy.胆碱转运蛋白样蛋白 1（CTL1）在小细胞肺癌细胞中的功能表达：肺癌治疗的靶标分子。
Pharmacol Res. 2013 Oct;76:119-31. doi: 10.1016/j.phrs.2013.07.011. Epub 2013 Aug 13.
9
Protein kinase C promotes choline transporter‑like protein 1 function via improved cell surface expression in immortalized human hepatic cells.蛋白激酶 C 通过提高永生化人肝细胞中胆碱转运蛋白样蛋白 1 的细胞表面表达来促进其功能。
Mol Med Rep. 2020 Feb;21(2):777-785. doi: 10.3892/mmr.2019.10894. Epub 2019 Dec 18.
10
Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake.神经母细胞瘤x胶质瘤细胞及中枢神经系统中胆碱转运体样蛋白1（CTL1）的检测及其在胆碱摄取中的作用。
J Neurochem. 2009 Aug;110(4):1297-309. doi: 10.1111/j.1471-4159.2009.06218.x. Epub 2009 Jun 10.

引用本文的文献

1
Choline in immunity: a key regulator of immune cell activation and function.胆碱在免疫中的作用：免疫细胞激活与功能的关键调节因子
Front Immunol. 2025 Aug 1;16:1617077. doi: 10.3389/fimmu.2025.1617077. eCollection 2025.
2
The Role of Uridine in Health and Disease.尿苷在健康与疾病中的作用。
J Inflamm Res. 2025 Jul 29;18:10163-10179. doi: 10.2147/JIR.S506308. eCollection 2025.
3
Feeding rumen-protected choline during the periconceptional period programs postnatal phenotype of suckled beef calves.在围产期给瘤胃保护性胆碱可调控哺乳肉用犊牛的产后表型。
J Anim Sci Biotechnol. 2025 Apr 2;16(1):48. doi: 10.1186/s40104-025-01188-8.
4
Cellular and organismal function of choline metabolism.胆碱代谢的细胞与机体功能
Nat Metab. 2025 Jan;7(1):35-52. doi: 10.1038/s42255-024-01203-8. Epub 2025 Jan 8.
5
The role of prenatal choline and its impact on neurodevelopmental disorders.产前胆碱的作用及其对神经发育障碍的影响。
Front Nutr. 2024 Nov 18;11:1463983. doi: 10.3389/fnut.2024.1463983. eCollection 2024.
6
Role of Magnetic Resonance Spectroscopy in Evaluating Choline Levels in Gallbladder Carcinoma: A Comprehensive Review.磁共振波谱在评估胆囊癌中胆碱水平的作用：一项综述
Cureus. 2024 Aug 5;16(8):e66205. doi: 10.7759/cureus.66205. eCollection 2024 Aug.
7
EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis.在 ER-HER2+ 乳腺癌细胞中敲低 EDI3 可减少两种实验性转移小鼠模型中的肿瘤负担并提高存活率。
Breast Cancer Res. 2024 May 30;26(1):87. doi: 10.1186/s13058-024-01849-y.
8
Cholinergic Mechanisms in Gastrointestinal Neoplasia.胆碱能机制在胃肠道肿瘤中的作用。
Int J Mol Sci. 2024 May 13;25(10):5316. doi: 10.3390/ijms25105316.
9
Acetylcholinesterase enzyme among cancer patients a potential diagnostic and prognostic indicator a multicenter case-control study.乙酰胆碱酯酶酶在癌症患者中的潜在诊断和预后指标：一项多中心病例对照研究。
Sci Rep. 2024 Mar 1;14(1):5127. doi: 10.1038/s41598-024-55604-6.
10
Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy.利用空间分辨代谢组学发现代谢脆弱性，以开发抗肿瘤小分子药物偶联物作为一种精准癌症治疗策略。
J Pharm Anal. 2023 Jul;13(7):776-787. doi: 10.1016/j.jpha.2023.02.010. Epub 2023 Feb 28.

本文引用的文献

1
Dietary Choline Intake: Current State of Knowledge Across the Life Cycle.膳食胆碱摄入量：全生命周期知识现状。
Nutrients. 2018 Oct 16;10(10):1513. doi: 10.3390/nu10101513.
2
Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism.候选基因通过 DNA 甲基化将母体营养暴露与后代健康联系起来：对人类现有证据的综述，特别关注一碳代谢。
Int J Epidemiol. 2018 Dec 1;47(6):1910-1937. doi: 10.1093/ije/dyy153.
3
Maternal betaine supplementation affects fetal growth and lipid metabolism of high-fat fed mice in a temporal-specific manner.母体甜菜碱补充以时间特异性的方式影响高脂肪喂养小鼠的胎儿生长和脂质代谢。
Nutr Diabetes. 2018 May 24;8(1):41. doi: 10.1038/s41387-018-0035-z.
4
Choline transport links macrophage phospholipid metabolism and inflammation.胆碱转运将巨噬细胞的磷脂代谢与炎症联系起来。
J Biol Chem. 2018 Jul 20;293(29):11600-11611. doi: 10.1074/jbc.RA118.003180. Epub 2018 Jun 7.
5
Dietary Modulation of the Epigenome.饮食对表观基因组的调控。
Physiol Rev. 2018 Apr 1;98(2):667-695. doi: 10.1152/physrev.00010.2017.
6
Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets.食管癌细胞中胆碱转运体样蛋白的分子与功能特征及潜在治疗靶点
Biomol Ther (Seoul). 2018 Jul 1;26(4):399-408. doi: 10.4062/biomolther.2017.113.
7
Neuroprotective Actions of Dietary Choline.膳食胆碱的神经保护作用
Nutrients. 2017 Jul 28;9(8):815. doi: 10.3390/nu9080815.
8
Acetylcholine-related proteins in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia.结直肠肿瘤患者非肿瘤性表现结肠黏膜中与乙酰胆碱相关的蛋白质
Mol Carcinog. 2017 Oct;56(10):2223-2233. doi: 10.1002/mc.22675. Epub 2017 Jun 15.
9
Choline, Other Methyl-Donors and Epigenetics.胆碱、其他甲基供体与表观遗传学。
Nutrients. 2017 Apr 29;9(5):445. doi: 10.3390/nu9050445.
10
Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants.母亲摄入甲基供体影响婴儿代谢基因的DNA甲基化。
Clin Epigenetics. 2017 Feb 7;9:16. doi: 10.1186/s13148-017-0321-y. eCollection 2017.