Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.
Nat Prod Res. 2020 Dec;34(23):3432-3436. doi: 10.1080/14786419.2019.1573820. Epub 2019 Feb 19.
Increase in adiposity is associated with obesity and obesity-related complications. Syringic acid (SA), a phenolic acid facilitates oxidation, polymerization, and condensation reactions, may function as an effective anti-adipogenic agent. This study examined whether SA inhibits adipogenesis in 3T3-L1 preadipocytes by inhibiting differentiation and controlling lipid accumulation. Ten days of SA treatment suppressed differentiation of 3T3-L1 preadipocyte to mature adipocytes in a concentration-dependent manner as determined by Oil Red O staining. Suppression of adipogenic differentiation by SA was primarily from inhibition of mitotic clonal expansion during the early stages of differentiation. Treatment of adipocytes with SA reduced triglyceride production (lipogenesis) and increased glycerol release (lipolysis). The addition of SA to the adipocytes attenuated ROS production. These results indicate that SA inhibits the adipogenesis of 3T3-L1 preadipocytes, reduces lipid accumulation, and attenuates ROS accumulation, suggesting for the first time that SA has an anti-obesity effect .
肥胖与肥胖相关并发症有关。丁香酸（SA）是一种酚酸，可促进氧化、聚合和缩合反应，可能是一种有效的抗脂肪生成剂。本研究通过抑制分化和控制脂质积累，探讨了 SA 是否抑制 3T3-L1 前脂肪细胞的脂肪生成。用 SA 处理 10 天可抑制油红 O 染色确定的 3T3-L1 前脂肪细胞向成熟脂肪细胞的分化，呈浓度依赖性。SA 对脂肪生成的抑制作用主要来自于分化早期有丝分裂克隆扩张的抑制。用 SA 处理脂肪细胞可减少甘油三酯的产生（脂肪生成）和增加甘油的释放（脂肪分解）。向脂肪细胞中添加 SA 可减轻 ROS 的产生。这些结果表明，SA 可抑制 3T3-L1 前脂肪细胞的脂肪生成，减少脂质积累，并减轻 ROS 的积累，这表明 SA 具有抗肥胖作用。
