CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, Chaoyang, China.
Org Biomol Chem. 2019 Mar 6;17(10):2646-2650. doi: 10.1039/c9ob00270g.
Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.
使用己二酸二酰肼交联剂实现了碳水化合物和多肽的化学选择性连接。碳水化合物的还原端在两步中有效地连接到肽上，以高产率和高区域选择性构建糖缀合物，从而能够生产出均一的糖缀合物。
