Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2019 Feb;23(3):1322-1334. doi: 10.26355/eurrev_201902_17027.
Neoplastic disease is frequently associated with poor nutritional status or severe malnutrition. Diet and nutritional intervention are becoming increasingly important for prognosis and quality of life in cancer patients. Accessible and repeatable tools for assessing nutritional status with body composition techniques seems to be fundamental. The aim of this study was to evaluate the effects of immunonutrition on body composition parameters, inflammatory response and nutritional status in patients at stage III of head and neck squamous carcinoma (HNSCC).
In our work, 50 malnourished subjects with HNSCC staging III were recruited and treated with oral diet (OD) or enteral nutrition (EN). Patient under EN followed, for the first three days, enteral standard nutrition (ESN) and then enteral immunonutrition (EIN). Nutrition state was evaluated on days 0, 3, and 8 through body composition and biochemical analyses.
After 8 days, the EIN treatment showed a significant improvement in phase angle, pre-albumin, retinol binding protein and transferrin compared to the OD treatment.
Our results showed that immunonutrition treatment improves the nutritional status of neoplastic patients, supporting chemotherapy. The phase angle is not only a predictor of cancer survival, but has also proved to be useful in the surveillance of nutritional status improvement as well as biochemical indices.
肿瘤疾病常伴有营养状况不良或严重营养不良。饮食和营养干预对于癌症患者的预后和生活质量变得越来越重要。用于评估营养状况和身体成分技术的可及和可重复的工具似乎是基础。本研究旨在评估免疫营养对 III 期头颈部鳞状细胞癌（HNSCC）患者身体成分参数、炎症反应和营养状况的影响。
在我们的工作中，招募了 50 名营养不良的 III 期 HNSCC 患者，并分别接受口服饮食（OD）或肠内营养（EN）治疗。接受 EN 治疗的患者在前三天接受标准肠内营养（ESN），然后接受肠内免疫营养（EIN）。通过身体成分和生化分析，在第 0、3 和 8 天评估营养状况。
8 天后，EIN 治疗组与 OD 治疗组相比，相位角、前白蛋白、视黄醇结合蛋白和转铁蛋白显著改善。
我们的结果表明，免疫营养治疗可改善肿瘤患者的营养状况，支持化疗。相位角不仅是癌症生存的预测指标，而且已被证明在监测营养状况改善和生化指标方面也很有用。
