Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
School of Specialization in Food Science, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Genes (Basel). 2023 Jan 13;14(1):206. doi: 10.3390/genes14010206.
The Mediterranean Diet (MedDiet) is associated with beneficial effects against chronic non-communicable diseases (CNCDs). In particular, the content of micronutrients leads to an improvement of the oxidative and inflammatory profiles. A randomized, parallel, controlled study, on 24 subjects, was conducted to evaluate if 2-week supplementation with a mixed apple and bergamot juice (MAB juice), had a positive impact on the body composition, the biochemical profile, and oxidative and inflammatory gene expression (Superoxide dismutase (SOD1), Peroxisome Proliferator-Activated Receptor γ (PPARγ), catalase (CAT), chemokine C-C motif ligand 5 (CCL5), Nuclear Factor Kappa B Subunit 1 (NFKB1), Vitamin D Receptor (VDR), and Macrophage Migration Inhibitory Factor (MIF)), respect to a MedDiet. Body composition evaluation analysis showed a gain in lean mass (p < 0.01). Moreover, a significant reduction in total cholesterol/HDL index (p < 0.01) was pointed out between the two groups. Gene expression analysis highlighted an increase in MIF (p ≤ 0.05), PPARγ (p < 0.001), SOD1 (p ≤ 0.05), and VDR (p ≤ 0.05) expressions when comparing MedDiet and MedDiet + MAB juice groups. These data based on the nutrigenomics approach demonstrated that supplementing 2 weeks of MAB juice to the MedDiet could contribute to a reduction in the risk of CNCDs.
地中海饮食（MedDiet）与慢性非传染性疾病（CNCDs）的有益作用有关。特别是，微量元素的含量改善了氧化和炎症谱。进行了一项随机、平行、对照研究，共纳入 24 名受试者，旨在评估 2 周补充混合苹果和佛手柑汁（MAB 汁）是否对人体成分、生化谱以及氧化和炎症基因表达（超氧化物歧化酶（SOD1）、过氧化物酶体增殖物激活受体γ（PPARγ）、过氧化氢酶（CAT）、趋化因子 C-C 基元配体 5（CCL5）、核因子κB 亚单位 1（NFKB1）、维生素 D 受体（VDR）和巨噬细胞移动抑制因子（MIF））产生积极影响，与 MedDiet 相比。人体成分评估分析显示，瘦体重增加（p<0.01）。此外，两组之间总胆固醇/高密度脂蛋白指数（p<0.01）显著降低。基因表达分析突出表明，与 MedDiet 组相比，MAB 汁组 MIF（p≤0.05）、PPARγ（p<0.001）、SOD1（p≤0.05）和 VDR（p≤0.05）的表达增加。基于营养基因组学方法的数据表明，在 MedDiet 中补充 2 周的 MAB 汁可能有助于降低 CNCDs 的风险。
