ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.
J Clin Periodontol. 2019 Mar;46(3):342-353. doi: 10.1111/jcpe.13088.
To evaluate the efficacy of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse, as an adjunct to professionally and patient-administered mechanical plaque removal, in the treatment of peri-implant mucositis (PiM).
Patients displaying PiM in, at least, one implant were included in this randomized, double-blinded, clinical trial. Subjects received professional prophylaxis (baseline and 6 months) and were instructed to regular oral hygiene practices and to rinse, twice daily, with the test or placebo mouth rinses, during one year. Clinical, radiographic and microbiological outcomes were evaluated at baseline, 6 and 12 months. Disease resolution was defined as absence of bleeding on probing (BOP). Data were analysed by repeated measures ANOVA, Student's t and chi-square tests.
Fifty-four patients were included and 46 attended the final visit (22 in control and 24 in test group). In the test group, there was a 24.49% greater reduction in BOP at the buccal sites (95% confidence interval [3.65-45.34%]; p = 0.002) than in controls. About 58.3% of test implants and 50% controls showed healthy peri-implant tissues at final visit (p > 0.05).
The use of the test mouth rinse demonstrated some adjunctive benefits in the treatment of PiM. Complete disease resolution could not be achieved in every case.
评估 0.03%洗必泰和 0.05%十六烷基吡啶氯口腔冲洗液作为专业和患者辅助机械菌斑去除的辅助手段，在治疗种植体周围黏膜炎（PiM）中的疗效。
本随机、双盲、临床试验纳入了至少一个种植体存在 PiM 的患者。受试者接受专业预防措施（基线和 6 个月），并被指示定期进行口腔卫生，并在一年内每天两次使用试验或安慰剂漱口液漱口。在基线、6 个月和 12 个月时评估临床、放射和微生物学结果。疾病缓解定义为探诊无出血（BOP）。数据通过重复测量方差分析、学生 t 检验和卡方检验进行分析。
54 名患者入组，46 名患者完成了最终随访（对照组 22 名，试验组 24 名）。在试验组，颊侧 BOP 减少了 24.49%（95%置信区间 [3.65-45.34%]；p=0.002），而对照组则减少了 95%置信区间 [3.65-45.34%]。在最终随访时，试验组约有 58.3%的种植体和 50%的对照组显示出健康的种植体周围组织（p>0.05）。
使用试验漱口液在治疗 PiM 方面显示出一些辅助益处。并非每个病例都能达到完全的疾病缓解。
