Ohnaka Keizo, Kono Suminori
a Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
b
Expert Rev Endocrinol Metab. 2010 Nov;5(6):891-904. doi: 10.1586/eem.10.65.
Owing to a potent antioxidant property of bilirubin, a growing interest has been drawn to the potential protective effects of bilirubin against oxidative stress-related diseases. This article evaluates associations of bilirubin with atherosclerotic diseases and cancer. Serum bilirubin has consistently been shown to be inversely associated with diverse atherosclerotic diseases, mostly among men in different populations. A limited number of prospective studies have shown a U-shaped or reversed J-shaped relationship between bilirubin and coronary heart disease in men and no evident association in women. Few studies have provided evidence supportive of a protective association between bilirubin and cancer risk. The findings on bilirubin-related genetic polymorphisms are inconsistent in relation to coronary heart disease and cancer.
由于胆红素具有强大的抗氧化特性，其对氧化应激相关疾病的潜在保护作用已引起越来越多的关注。本文评估了胆红素与动脉粥样硬化疾病和癌症之间的关联。血清胆红素一直被证明与多种动脉粥样硬化疾病呈负相关，这一现象在不同人群的男性中最为常见。少数前瞻性研究表明，男性胆红素与冠心病之间呈U形或倒J形关系，而女性中则无明显关联。很少有研究能提供证据支持胆红素与癌症风险之间存在保护性关联。关于胆红素相关基因多态性与冠心病和癌症的研究结果并不一致。
