School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago.
Biochemistry Unit, Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago.
BMJ Open. 2019 Feb 19;9(2):e024029. doi: 10.1136/bmjopen-2018-024029.
To develop a novel sex independent anthropometric index, termed as angle index, related to type 2 diabetes.
Case-control.
The study comprised 121 participants and were divided into two groups. One group had no form of diabetes and served as controls (n=50). The other group had the condition of type 2 diabetes (n=71). 31% (n=37) of the subjects were male and 69% (n=84) were female. 62% (n=75) of the subjects were of East Indian ethnicity, 28% (n=34) were of African ethnicity and 10% (n=12) were of mixed ethnicity.
Participants of the study were from the island of Trinidad, located in the Caribbean. Patients in the study were selected at random from hospital records.
It was hypothesised that the mean angle index of patients with type 2 diabetes would be higher than the mean angle index of patients without type 2 diabetes.
Patients with type 2 diabetes had a significantly higher angle index value as compared with controls (p<0.001). Angle index was the superior sex independent anthropometric index in relation to type 2 diabetes (area under the curve=0.72; p<0.001) as compared with other sex independent variables. Angle index correlated with glycated haemoglobin (r=0.28, p=0.003) and fasting blood glucose (r=0.31, p=0.001) levels. Patients with type 2 diabetes were four times more likely to have an angle index greater than 184° (OR 4.2, 95% CI 1.8 to 9.9) as compared with controls.
Angle index was a superior sex independent index for discriminating between patients with and without type 2 diabetes, as compared with waist circumference, abdominal volume index, conicity index, blood pressure readings, triglyceride levels and very low-density lipoprotein levels.
开发一种新的与 2 型糖尿病相关的性别独立人体测量指数，称为角度指数。
病例对照研究。
本研究包括 121 名参与者，分为两组。一组没有任何形式的糖尿病，作为对照组（n=50）。另一组患有 2 型糖尿病（n=71）。31%（n=37）的受试者为男性，69%（n=84）为女性。62%（n=75）的受试者为东印度裔，28%（n=34）为非洲裔，10%（n=12）为混合裔。
本研究的参与者来自加勒比海的特立尼达岛。研究中的患者是从医院记录中随机选择的。
假设 2 型糖尿病患者的平均角度指数高于无 2 型糖尿病患者的平均角度指数。
2 型糖尿病患者的角度指数显著高于对照组（p<0.001）。与其他性别独立变量相比，角度指数是与 2 型糖尿病相关的更好的性别独立人体测量指数（曲线下面积=0.72；p<0.001）。角度指数与糖化血红蛋白（r=0.28，p=0.003）和空腹血糖（r=0.31，p=0.001）水平相关。与对照组相比，2 型糖尿病患者角度指数大于 184°的可能性高出四倍（比值比 4.2，95%置信区间 1.8 至 9.9）。
与腰围、腹围指数、圆锥指数、血压读数、甘油三酯水平和极低密度脂蛋白水平相比，角度指数是区分 2 型糖尿病患者和非 2 型糖尿病患者的更好的性别独立指标。
