Tomic Svetlana, Kuric Tihana Gilman, Popovic Zvonimir, Zubonja Tea Mirosevic
Department of Neurology, Osijek University Hospital Centre, J. Huttlera 4, Osijek, Croatia.
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, J. Huttlera 4, HR-31000, Osijek, Croatia.
Neurol Sci. 2022 Jan;43(1):373-378. doi: 10.1007/s10072-021-05322-y. Epub 2021 May 20.
Dystonia is a movement disorder presented with involuntary muscle contraction causing abnormal posture, movement, or both. Besides motor symptoms, patients may also report non-motor symptoms such as pain, anxiety, apathy, depression, sleep problems, fatigue, and cognitive impairment. The etiology of fatigue in patients with dystonia is not yet well understood.
To evaluate the presence of fatigue, depression, anxiety, sleep disorders, and daily sleepiness in patients with focal and segmental dystonia and to determine which of these non-motor symptoms influence the occurrence and severity of fatigue.
Patients were surveyed for symptoms of fatigue, depression, anxiety, night-time sleep problems, and daily sleepiness using the Fatigue Assessment Scale, Beck Depression Inventory II, Beck Anxiety Inventory, Pittsburgh Sleep Questionnaire Index, and Epworth Sleepiness Scale. Demographic data (sex, age, and disease duration) were collected from patient medical records. On statistical analysis, we used SPSS for Windows 10. The level of significance was set at p<0.05.
Sixty patients (43 female and 17 male) with focal or segmental dystonia were evaluated. Fatigue was reported by 67.2% of patients. Fatigue (general, physical, and mental fatigue) was found to correlate with depression, anxiety, and sleep problems. Daily sleepiness correlated only with mental fatigue. Disease duration, age, and gender did not influence the symptoms of fatigue. Multiple regression analysis showed that depression mostly predicted symptoms of general, physical, and mental fatigue.
Depression mostly predicted symptoms of general, physical, and mental fatigue in patients with focal and segmental dystonia.
肌张力障碍是一种运动障碍，表现为不自主的肌肉收缩，导致异常姿势、运动或两者皆有。除运动症状外，患者还可能报告疼痛、焦虑、冷漠、抑郁、睡眠问题、疲劳和认知障碍等非运动症状。肌张力障碍患者疲劳的病因尚未完全明确。
评估局限性和节段性肌张力障碍患者中疲劳、抑郁、焦虑、睡眠障碍和日间嗜睡的情况，并确定这些非运动症状中哪些会影响疲劳的发生和严重程度。
使用疲劳评估量表、贝克抑郁量表第二版、贝克焦虑量表、匹兹堡睡眠质量指数和爱泼华嗜睡量表对患者进行疲劳、抑郁、焦虑、夜间睡眠问题和日间嗜睡症状的调查。从患者病历中收集人口统计学数据（性别、年龄和病程）。在统计分析中，我们使用Windows 10版的SPSS。显著性水平设定为p<0.05。
对60例局限性或节段性肌张力障碍患者（43例女性和17例男性）进行了评估。67.2%的患者报告有疲劳症状。发现疲劳（全身、身体和精神疲劳）与抑郁、焦虑和睡眠问题相关。日间嗜睡仅与精神疲劳相关。病程、年龄和性别不影响疲劳症状。多元回归分析表明，抑郁最能预测全身、身体和精神疲劳症状。
抑郁最能预测局限性和节段性肌张力障碍患者的全身、身体和精神疲劳症状。
