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越南女性剖宫产瘢痕妊娠的管理

Management of Cesarean Scar Pregnancy among Vietnamese Women.

作者信息

Vo Tuan Minh, Van Thong, Nguyen Long, Tran Quynh

机构信息

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.

Department of Gynecology, Tudu Hospital, Ho Chi Minh City, Vietnam.

出版信息

Gynecol Minim Invasive Ther. 2019 Jan-Mar;8(1):12-18. doi: 10.4103/GMIT.GMIT_8_18. Epub 2019 Jan 23.

Abstract

OBJECTIVE

To demonstrate the efficacy of management for cesarean scar ectopic pregnancies up to 8 weeks' gestation using ultrasound-guided Foley balloon catheter placement combined with dilation and curettage (D and C) at TuDu Hospital.

SUBJECTS AND METHODS

A quasi-experimental study was conducted from March 2015 to March 2016. Patients with imaging-confirmed cesarean ectopic pregnancies were admitted to an inpatient unit at Tu Du Hospital. A Foley balloon catheter was placed inside the uterus under ultrasound guidance and was left in place for 24 h. Afterward, the patient underwent ultrasound-guided D and C. Follow-up to confirm success included serial blood draws to measure beta-human chorionic gonadotropin (β-hCG) levels until a value of 0, and routine ultrasounds to confirm absence of a gestational sac and no evidence of vascularity at the site of the cesarean section scar.

RESULTS

A total of 311 patients were enrolled over 3 months. Overall, 90.7% (95% confidence interval [CI]: 86.8%-93.9%) patients were successfully treated with this regimen. Several factors that were significantly associated with successful management included gestational age <6 weeks (odds ratio [OR] 3.1, 95% CI: 1.03%-8.76%), β-hCG level <11,000 mUI/mL before discharge from the hospital (OR 6.5, 95% CI: 1.42%-30.6%), gestational sac volume 2 weeks after treatment measuring <5 cm (OR 9.1, 95% CI: 1.96%-50.1%).

CONCLUSIONS

This is an easily applicable method with a short follow-up period and reduction in treatment costs compared to standard treatment with methotrexate injection.

摘要

目的

在涂都医院证明超声引导下放置福来导尿管联合刮宫术(D和C)治疗妊娠8周以内剖宫产瘢痕部位异位妊娠的疗效。

对象与方法

2015年3月至2016年3月进行了一项准实验研究。影像学确诊为剖宫产瘢痕部位异位妊娠的患者入住涂都医院的住院部。在超声引导下将福来导尿管放置于子宫内并留置24小时。之后,患者接受超声引导下的刮宫术。随访确认成功包括连续抽血检测β-人绒毛膜促性腺激素(β-hCG)水平直至值为0,以及常规超声检查以确认剖宫产瘢痕部位无妊娠囊且无血管迹象。

结果

3个月内共纳入311例患者。总体而言,90.7%(95%置信区间[CI]:86.8%-93.9%)的患者通过该方案成功治疗。与成功治疗显著相关的几个因素包括孕周<6周(比值比[OR] 3.1,95% CI:1.03%-8.76%)、出院前β-hCG水平<11,000 mUI/mL(OR 6.5,95% CI:1.42%-30.6%)、治疗2周后妊娠囊体积<5 cm(OR 9.1,95% CI:1.96%-50.1%)。

结论

与甲氨蝶呤注射的标准治疗相比,这是一种易于应用的方法,随访期短且治疗成本降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c9/6367916/757a5849ae04/GMIT-8-12-g001.jpg

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