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刮宫术是剖宫产瘢痕妊娠的一种有效治疗选择吗?

Is suction curettage an effective treatment alternative for cesarean scar pregnancies?

作者信息

Bağlı İhsan, Bakır Mehmet Sait, Doğan Yasemin, Erdem Selami, Taşın Cuma, Demirel Neslihan Uğur, Kulahçıoğlu Mehmet İrfan

机构信息

University of Health Sciences Diyarbakir Gazi Yasargil Research and Training Hospital, Department of Obstetrics and Gynecology, Diyarbakır, Turkey.

University of Health Sciences Diyarbakir Gazi Yasargil Research and Training Hospital, Department of Obstetrics and Gynecology, Diyarbakır, Turkey.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2021 Mar;258:193-197. doi: 10.1016/j.ejogrb.2021.01.002. Epub 2021 Jan 6.

Abstract

OBJECTIVES

The study aims to evaluate the success rate of suction curettage (SC) as a first line treatment with or without use of foley balloon tamponade for cesarean scar pregnancy (CSP) and to determine the risk factors for failure of treatment.

STUDY DESIGN

The study was retrospective and included 36 CSP cases who underwent SC for treatment. Presence of pain with active bleeding and > 10 weeks of gestation were taken as the exclusion criterion. The procedure was performed under sonographic guidance. After the procedure, in patients who had a hemorrhage foley catheter was inserted into the uterine cavity. SC failure was defined as a requirement of secondary intervention. CSP types, myometrial thickness in the scar area, fetal cardiac activity, initial Beta human chorionic gonadotropin levels (β-HCG), history of vaginal delivery were compared between successful and failed groups.

RESULT

Of 36 patients, 31 had favorable results with SC ± foley balloon tamponade. Success rate was found to be 86 % (31/36) as the first line therapy. Foley catheter was applied for 23 patients, among them, four were in the failed group and 19 were in the favorable group. In the failed group, two patients had emergent laparotomy, two had repeat SC the day after the initial treatment and one patient was treated with systemic MTX. Fetal cardiac activity and presence of embryonic pole were not different between the groups (p = 1.000, p = 0.829 respectively). Myometrial thickness in the failed group was less than the successful group, this difference was significant (p = 0.033). CSP types, initial β-HCG levels and history of vaginal delivery were not different between the groups (p = 0.149, p = 0.372 and p = 0.404 respectively).

CONCLUSION

SC may be considered as a first line therapy for CSPs, and and in patients complicated with hemorrhage foley balloon tamponade can be used easily. Thinner myometrium at previous cesarean scar can be considered as a risk factor for failure of SC in patients with CSP.

摘要

目的

本研究旨在评估刮宫术(SC)作为剖宫产瘢痕妊娠(CSP)一线治疗方法(无论是否使用 Foley 球囊填塞)的成功率,并确定治疗失败的风险因素。

研究设计

本研究为回顾性研究,纳入了 36 例行 SC 治疗的 CSP 病例。将有活动性出血伴疼痛以及妊娠超过 10 周作为排除标准。该手术在超声引导下进行。术后,对出现出血的患者将 Foley 导管插入宫腔。SC 失败定义为需要二次干预。比较成功组和失败组之间的 CSP 类型、瘢痕区域的肌层厚度、胎儿心搏、初始β-人绒毛膜促性腺激素水平(β-HCG)、阴道分娩史。

结果

36 例患者中,31 例采用 SC±Foley 球囊填塞取得了良好效果。作为一线治疗方法,成功率为 86%(31/36)。23 例患者应用了 Foley 导管,其中 4 例在失败组,19 例在成功组。在失败组中,2 例患者进行了急诊剖腹手术,2 例在初始治疗后第二天进行了重复刮宫术,1 例患者接受了全身甲氨蝶呤治疗。两组之间胎儿心搏和胎芽的存在情况无差异(分别为 p = 1.000,p = 0.829)。失败组的肌层厚度小于成功组,差异有统计学意义(p = 0.033)。两组之间的 CSP 类型、初始β-HCG 水平和阴道分娩史无差异(分别为 p = 0.149,p = 0.372 和 p = 0.404)。

结论

SC 可被视为 CSP 的一线治疗方法,对于合并出血的患者,Foley 球囊填塞可轻松应用。既往剖宫产瘢痕处肌层较薄可被视为 CSP 患者 SC 治疗失败的一个风险因素。

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