Li Ke, Nicoli Fabio, Xi Wen Jing, Zhang Zheng, Cui Chunxiao, Al-Mousawi Ahmed, Balzani Alberto, Tong Yun, Zhang Yixin
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011 China.
2Department of Plastic and Reconstructive Surgery, University of Rome "Tor Vergata", Rome, Italy.
Burns Trauma. 2019 Feb 15;7:5. doi: 10.1186/s41038-019-0143-6. eCollection 2019.
Keloids are the result of abnormal wound healing and often are subject to infections and recurrent inflammation. We present a study conducted with a 1470 nm diode laser using an intralesional optical fiber device for the treatment of inflamed keloid scars. We evaluate its efficacy as a novel alternative method to decrease keloid infection and inflammation.
The patients who underwent 1470 nm laser treatment from February 2016 to February 2018 at the plastic and reconstructive surgery department of the Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University with keloid accompanying serious local infection and fester were included. Patients took curative effect evaluation before and 1 year after the treatment. The test items included infection frequency in each year; pain, by visual analogue scale (VAS); itch, using VAS; quality of life (QOL), using QOL scale; and blood supply, using PeriCam PSI.
A total of 19 patients (mean age 35.21 years, range 11-66) with history of inflamed keloids with episodes of infection or abscess were enrolled. Patients underwent to a 1470 nm laser therapy for average of 1.16 times. After treatment, infection frequency and blood supply in keloids were reduced ( < 0.001). Pain, itching, and QOL were improved ( < 0.001).
The present study shows that 1470 nm fiber laser treatment could improve inflamed keloids fairly well by decreasing inflammation, and a relative stabilization of collagen composition. Therefore, it is an effective minimally invasive scar therapy, but further studies are essential to confirm the present results.
瘢痕疙瘩是伤口异常愈合的结果，常伴有感染和反复炎症。我们开展了一项研究，使用1470纳米二极管激光及病灶内光纤装置治疗炎性瘢痕疙瘩。我们评估其作为一种减少瘢痕疙瘩感染和炎症的新型替代方法的疗效。
纳入2016年2月至2018年2月在上海交通大学附属第九人民医院整形外科接受1470纳米激光治疗且伴有严重局部感染和化脓的瘢痕疙瘩患者。患者在治疗前及治疗后1年进行疗效评估。测试项目包括每年的感染频率；采用视觉模拟评分法（VAS）评估疼痛；采用VAS评估瘙痒；采用生活质量量表评估生活质量（QOL）；采用PeriCam PSI评估血供。
共纳入19例（平均年龄35.21岁，范围11 - 66岁）有炎性瘢痕疙瘩且有感染或脓肿发作史的患者。患者平均接受1470纳米激光治疗1.16次。治疗后，瘢痕疙瘩的感染频率和血供降低（<0.001）。疼痛、瘙痒和生活质量得到改善（<0.001）。
本研究表明，1470纳米光纤激光治疗可通过减轻炎症及使胶原蛋白组成相对稳定，较好地改善炎性瘢痕疙瘩。因此，它是一种有效的微创瘢痕治疗方法，但需要进一步研究来证实目前的结果。
