Department of Medicine, Veterans Affairs Medical Center, La Jolla, CA 92161, USA; La Jolla Pharmaceutical Company, 4550 Towne Centre Court, San Diego, CA 92121, USA.
La Jolla Pharmaceutical Company, 4550 Towne Centre Court, San Diego, CA 92121, USA.
Crit Care Clin. 2019 Apr;35(2):357-374. doi: 10.1016/j.ccc.2018.11.014. Epub 2019 Jan 30.
Iron homeostasis is often disrupted in acute disease with an increase in catalytic free iron leading to the formation of reactive oxygen species and subsequent tissue-specific oxidative damage. This article highlights the potential therapeutic benefit of exogenous hepcidin to prevent and treat iron-induced injury, specifically in the management of infection from enteric gram-negative bacilli or fungi, malaria, sepsis, acute kidney injury, trauma, transfusion, cardiopulmonary bypass surgery, and liver disease.
铁稳态在急性疾病中经常被打乱，催化游离铁的增加导致活性氧的形成和随后的组织特异性氧化损伤。本文强调了外源性铁调素预防和治疗铁诱导损伤的潜在治疗益处，特别是在管理肠革兰氏阴性杆菌或真菌、疟疾、败血症、急性肾损伤、创伤、输血、体外循环手术和肝病引起的感染方面。
