Electrophysiology Division, Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
JACC Clin Electrophysiol. 2019 Feb;5(2):245-251. doi: 10.1016/j.jacep.2018.09.016.
This study sought to determine the practical use of the recently introduced LINQ implantable loop recorder (LINQ-ILR) in a cohort of pediatric and adult congenital arrhythmia patients.
Correlating symptoms to a causative arrhythmia is a key aspect of diagnosis and management in clinical electrophysiology.
Retrospective review of clinical data, implantation indications, findings, and therapeutic decisions in patients who underwent LINQ-ILR implantation from April 1st, 2014 to January 30th, 2017 at Boston Children's Hospital.
A total of 133 patients were included, of which 76 (57%) were male. The mean age at implantation was 15.7 ± 9.1 years with a duration of follow-up of 11.8 months. Congenital heart disease was present in 34 patients (26%), a confirmed genetic diagnosis in 50 (38%), and cardiomyopathy in 22 (26%), and the remainder were without a previous diagnosis. Syncope was the most common indication for LINQ-ILR implantation, occurring in 59 patients (44%). The median time to diagnosis was 4.5 months, occurring in 78 patients (59%). Cardiac device placement occurred in 17 patients (22%), a medication change in 9 (12%), electrophysiology study/ablation in 5 (6%), or LINQ-ILR explantation in 42 (54%). Infection or erosion occurred in 5 patients. Syncope was correlated with a diagnostic transmission (54% vs. 31%, p = 0.01).
The LINQ-ILR is an important diagnostic tool, providing useful data in more than one-half of patients in <6 months. Adverse events are low. Patient selection is critical and undiagnosed syncope represents an important presenting indication for which a LINQ-ILR implant should be considered.
本研究旨在确定最近引入的 LINQ 植入式环路记录器(LINQ-ILR)在儿科和成人先天性心律失常患者中的实际应用。
将症状与致病心律失常相关联是临床电生理学诊断和管理的关键方面。
回顾性分析 2014 年 4 月 1 日至 2017 年 1 月 30 日期间在波士顿儿童医院接受 LINQ-ILR 植入的患者的临床数据、植入指征、发现和治疗决策。
共纳入 133 例患者,其中 76 例(57%)为男性。植入时的平均年龄为 15.7 ± 9.1 岁,随访时间为 11.8 个月。34 例(26%)患者存在先天性心脏病,50 例(38%)患者有明确的遗传诊断,22 例(26%)患者患有心肌病,其余患者无既往诊断。晕厥是 LINQ-ILR 植入的最常见指征,发生于 59 例患者(44%)。诊断中位时间为 4.5 个月,发生于 78 例患者(59%)。17 例(22%)患者进行了心脏装置放置,9 例(12%)进行了药物调整,5 例(6%)进行了电生理研究/消融,42 例(54%)进行了 LINQ-ILR 取出。5 例患者出现感染或侵蚀。晕厥与诊断传输相关(54% vs. 31%,p = 0.01)。
LINQ-ILR 是一种重要的诊断工具,在<6 个月的时间内为超过一半的患者提供了有用的数据。不良事件发生率低。患者选择至关重要,未诊断的晕厥是一个重要的临床表现指征,应考虑植入 LINQ-ILR。